Toxoplasma gondii Infection in Neonates
Background: To study toxoplasmosis in neonates using PCR and serological methods."nMethods: Sera and CSF of 104 neonates, hospitalized in infants' ward of Taleghani Hospital, Tehran, Iran were examined. The sera were examined for anti Toxoplasma gondii lgM and lgG specific antibodies w...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2007-07-01
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| Series: | Iranian Journal of Parasitology |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4015.pdf&manuscript_id=4015 |
| _version_ | 1818383172016013312 |
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| author | M Karamy ASA Mehbod M Shaddel |
| author_facet | M Karamy ASA Mehbod M Shaddel |
| author_sort | M Karamy |
| collection | DOAJ |
| description | Background: To study toxoplasmosis in neonates using PCR and serological methods."nMethods: Sera and CSF of 104 neonates, hospitalized in infants' ward of Taleghani Hospital, Tehran, Iran were examined. The sera were examined for anti Toxoplasma gondii lgM and lgG specific antibodies with ELISA and IFA techniques, respectively. Meanwhile, obtained CSFs of the cases were evaluated for the genome of this parasite by PCR technique."nResults: Results showed positivity in 7 neonates (6.73%) which suggested congenital toxoplasmosis. Results of PCR were positive in 6 neonates (5.77%). The 1/100 titer of lgM specific antibodies was positive in 5(4.81%) of them by IFA technique and 6 neonates (5.77%) had positive results by ELISA technique for IgM specific. The rate of mortality was %0.96. Forty one neonates had 1/200 titer of specific lgG antibodies by IFA technique and 38 neonates had positive results by ELISA technique for IgG antibodies. The prevalence of chronic toxoplasmosis in mother was 32.7% and 30% by IFA and ELISA techniques, respectively. "nConclusion: Toxoplasmosis is still highly prevalent in neonates and should be considered due to the fact that suspected cases might be misdiagnosed and subsequently led to life- threatening or fatal condition. |
| first_indexed | 2024-12-14T03:02:08Z |
| format | Article |
| id | doaj.art-fe90f7d3016d4556b440078940fcca2d |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-12-14T03:02:08Z |
| publishDate | 2007-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-fe90f7d3016d4556b440078940fcca2d2022-12-21T23:19:30ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2007-07-01233437Toxoplasma gondii Infection in NeonatesM KaramyASA MehbodM ShaddelBackground: To study toxoplasmosis in neonates using PCR and serological methods."nMethods: Sera and CSF of 104 neonates, hospitalized in infants' ward of Taleghani Hospital, Tehran, Iran were examined. The sera were examined for anti Toxoplasma gondii lgM and lgG specific antibodies with ELISA and IFA techniques, respectively. Meanwhile, obtained CSFs of the cases were evaluated for the genome of this parasite by PCR technique."nResults: Results showed positivity in 7 neonates (6.73%) which suggested congenital toxoplasmosis. Results of PCR were positive in 6 neonates (5.77%). The 1/100 titer of lgM specific antibodies was positive in 5(4.81%) of them by IFA technique and 6 neonates (5.77%) had positive results by ELISA technique for IgM specific. The rate of mortality was %0.96. Forty one neonates had 1/200 titer of specific lgG antibodies by IFA technique and 38 neonates had positive results by ELISA technique for IgG antibodies. The prevalence of chronic toxoplasmosis in mother was 32.7% and 30% by IFA and ELISA techniques, respectively. "nConclusion: Toxoplasmosis is still highly prevalent in neonates and should be considered due to the fact that suspected cases might be misdiagnosed and subsequently led to life- threatening or fatal condition.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4015.pdf&manuscript_id=4015 NeonatesPCRSerologyToxoplasma gondiiIran |
| spellingShingle | M Karamy ASA Mehbod M Shaddel Toxoplasma gondii Infection in Neonates Iranian Journal of Parasitology Neonates PCR Serology Toxoplasma gondii Iran |
| title | Toxoplasma gondii Infection in Neonates |
| title_full | Toxoplasma gondii Infection in Neonates |
| title_fullStr | Toxoplasma gondii Infection in Neonates |
| title_full_unstemmed | Toxoplasma gondii Infection in Neonates |
| title_short | Toxoplasma gondii Infection in Neonates |
| title_sort | toxoplasma gondii infection in neonates |
| topic | Neonates PCR Serology Toxoplasma gondii Iran |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4015.pdf&manuscript_id=4015 |
| work_keys_str_mv | AT mkaramy toxoplasmagondiiinfectioninneonates AT asamehbod toxoplasmagondiiinfectioninneonates AT mshaddel toxoplasmagondiiinfectioninneonates |