Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function.
We sought to quantify plasma high sensitivity cardiac troponin (hs-cTnT) levels, their determinants, and their associations with left ventricular (LV) myocardial deformation in adult survivors of childhood acute leukaemias.One hundred adult survivors (57 males) of childhood acute leukaemias, aged 24...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3804508?pdf=render |
| _version_ | 1818822758057902080 |
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| author | Yiu-fai Cheung Wei Yu Daniel Ka-leung Cheuk Frankie Wai-tsoi Cheng Janet Yee-kwan Yang Jeffrey Ping-wa Yau Karin Ka-huen Ho Chi-kong Li Rever Chak-ho Li Hui-Leung Yuen Alvin Siu-cheung Ling Vivian Wing-yi Li Wai-keung Wong Kwong-cheong Tsang Godfrey Chi-fung Chan |
| author_facet | Yiu-fai Cheung Wei Yu Daniel Ka-leung Cheuk Frankie Wai-tsoi Cheng Janet Yee-kwan Yang Jeffrey Ping-wa Yau Karin Ka-huen Ho Chi-kong Li Rever Chak-ho Li Hui-Leung Yuen Alvin Siu-cheung Ling Vivian Wing-yi Li Wai-keung Wong Kwong-cheong Tsang Godfrey Chi-fung Chan |
| author_sort | Yiu-fai Cheung |
| collection | DOAJ |
| description | We sought to quantify plasma high sensitivity cardiac troponin (hs-cTnT) levels, their determinants, and their associations with left ventricular (LV) myocardial deformation in adult survivors of childhood acute leukaemias.One hundred adult survivors (57 males) of childhood acute leukaemias, aged 24.1 ± 4.2 years, and 42 age-matched controls (26 males) were studied. Plasma cTnT was determined using a highly sensitive assay. Genotyping of NAD(P)H oxidase and multidrug resistance protein polymorphisms was performed. Left ventricular function was assessed by conventional, three-dimensional, and speckle tracking echocardiography. The medians (interquartile range) of hs-cTnT in male and female survivors were 4.9 (4.2 to 7.2) ng/L and 1.0 (1.0 to 3.5) ng/L, respectively. Nineteen survivors (13 males, 6 females) (19%) had elevated hs-cTnT (>95(th) centile of controls). Compared to those without elevated hs-TnT levels, these subjects had received larger cumulative anthracycline dose and were more likely to have leukaemic relapse, stem cell transplant, and cardiac irradiation. Their LV systolic and early diastolic myocardial velocities, isovolumic acceleration, and systolic longitudinal strain rate were significantly lower. Survivors having CT/TT at CYBA rs4673 had higher hs-cTnT levels than those with CC genotype. Functionally, increased hs-cTnT levels were associated with worse LV longitudinal systolic strain and systolic and diastolic strain rates.Increased hs-cTnT levels occur in a significant proportion of adult survivors of childhood acute leukaemias and are associated with larger cumulative anthracycline dose received, history of leukaemic relapse, stem cell transplant, and cardiac irradiation, genetic variants in free radical metabolism, and worse LV myocardial deformation. |
| first_indexed | 2024-12-18T23:29:10Z |
| format | Article |
| id | doaj.art-fe93015dbdbc46728702c782f2642834 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T23:29:10Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fe93015dbdbc46728702c782f26428342022-12-21T20:47:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7706310.1371/journal.pone.0077063Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function.Yiu-fai CheungWei YuDaniel Ka-leung CheukFrankie Wai-tsoi ChengJanet Yee-kwan YangJeffrey Ping-wa YauKarin Ka-huen HoChi-kong LiRever Chak-ho LiHui-Leung YuenAlvin Siu-cheung LingVivian Wing-yi LiWai-keung WongKwong-cheong TsangGodfrey Chi-fung ChanWe sought to quantify plasma high sensitivity cardiac troponin (hs-cTnT) levels, their determinants, and their associations with left ventricular (LV) myocardial deformation in adult survivors of childhood acute leukaemias.One hundred adult survivors (57 males) of childhood acute leukaemias, aged 24.1 ± 4.2 years, and 42 age-matched controls (26 males) were studied. Plasma cTnT was determined using a highly sensitive assay. Genotyping of NAD(P)H oxidase and multidrug resistance protein polymorphisms was performed. Left ventricular function was assessed by conventional, three-dimensional, and speckle tracking echocardiography. The medians (interquartile range) of hs-cTnT in male and female survivors were 4.9 (4.2 to 7.2) ng/L and 1.0 (1.0 to 3.5) ng/L, respectively. Nineteen survivors (13 males, 6 females) (19%) had elevated hs-cTnT (>95(th) centile of controls). Compared to those without elevated hs-TnT levels, these subjects had received larger cumulative anthracycline dose and were more likely to have leukaemic relapse, stem cell transplant, and cardiac irradiation. Their LV systolic and early diastolic myocardial velocities, isovolumic acceleration, and systolic longitudinal strain rate were significantly lower. Survivors having CT/TT at CYBA rs4673 had higher hs-cTnT levels than those with CC genotype. Functionally, increased hs-cTnT levels were associated with worse LV longitudinal systolic strain and systolic and diastolic strain rates.Increased hs-cTnT levels occur in a significant proportion of adult survivors of childhood acute leukaemias and are associated with larger cumulative anthracycline dose received, history of leukaemic relapse, stem cell transplant, and cardiac irradiation, genetic variants in free radical metabolism, and worse LV myocardial deformation.http://europepmc.org/articles/PMC3804508?pdf=render |
| spellingShingle | Yiu-fai Cheung Wei Yu Daniel Ka-leung Cheuk Frankie Wai-tsoi Cheng Janet Yee-kwan Yang Jeffrey Ping-wa Yau Karin Ka-huen Ho Chi-kong Li Rever Chak-ho Li Hui-Leung Yuen Alvin Siu-cheung Ling Vivian Wing-yi Li Wai-keung Wong Kwong-cheong Tsang Godfrey Chi-fung Chan Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function. PLoS ONE |
| title | Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function. |
| title_full | Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function. |
| title_fullStr | Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function. |
| title_full_unstemmed | Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function. |
| title_short | Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function. |
| title_sort | plasma high sensitivity troponin t levels in adult survivors of childhood leukaemias determinants and associations with cardiac function |
| url | http://europepmc.org/articles/PMC3804508?pdf=render |
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