INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/19 |
| _version_ | 1797198200449269760 |
|---|---|
| author | A. V. Zurochka E. V. Davydova D. A. Altman |
| author_facet | A. V. Zurochka E. V. Davydova D. A. Altman |
| author_sort | A. V. Zurochka |
| collection | DOAJ |
| description | Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,with amplified proliferative potential demonstrable in this group. We have also shown a trend to increasednumbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cellproliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectionalchanges of FasR expression were observed. However, the parameters reflecting readiness to apoptosis werechanged multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemiamay influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,causing an imbalance between cellular proliferation and apoptosis. |
| first_indexed | 2024-03-08T05:52:13Z |
| format | Article |
| id | doaj.art-fe9349e45d704ae08ac4398579ad9c21 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:56:05Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-fe9349e45d704ae08ac4398579ad9c212024-04-22T13:07:32ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01161273410.15789/1563-0625-2014-1-27-3419INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIAA. V. Zurochka0E. V. Davydova1D. A. Altman2Research Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch, EkaterinburgSouth Ural State Medical University, ChelyabinskSouth Ural State Medical University, ChelyabinskIncidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,with amplified proliferative potential demonstrable in this group. We have also shown a trend to increasednumbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cellproliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectionalchanges of FasR expression were observed. However, the parameters reflecting readiness to apoptosis werechanged multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemiamay influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,causing an imbalance between cellular proliferation and apoptosis.https://www.mimmun.ru/mimmun/article/view/19initial manifestation of insufficient blood supply to the braindyslipidemiaapoptosiscell proliferation |
| spellingShingle | A. V. Zurochka E. V. Davydova D. A. Altman INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA Медицинская иммунология initial manifestation of insufficient blood supply to the brain dyslipidemia apoptosis cell proliferation |
| title | INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA |
| title_full | INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA |
| title_fullStr | INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA |
| title_full_unstemmed | INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA |
| title_short | INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA |
| title_sort | intensity of apoptotic and proliferative events in lymphocytes under dyslipidemic conditions at early stages of chronic brain ischemia |
| topic | initial manifestation of insufficient blood supply to the brain dyslipidemia apoptosis cell proliferation |
| url | https://www.mimmun.ru/mimmun/article/view/19 |
| work_keys_str_mv | AT avzurochka intensityofapoptoticandproliferativeeventsinlymphocytesunderdyslipidemicconditionsatearlystagesofchronicbrainischemia AT evdavydova intensityofapoptoticandproliferativeeventsinlymphocytesunderdyslipidemicconditionsatearlystagesofchronicbrainischemia AT daaltman intensityofapoptoticandproliferativeeventsinlymphocytesunderdyslipidemicconditionsatearlystagesofchronicbrainischemia |