The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia
Objectives: Blood bank centers routinely screen for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) to ensure the safety of blood supply and thus prevent the dissemination of these viruses via blood transfusion. We sought to evaluate the detection of transfus...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2020-11-01
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| Series: | Oman Medical Journal |
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| Online Access: | http://omjournal.org/articleDetails.aspx?coType=1&aId=2776 |
| _version_ | 1819113049104056320 |
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| author | Marini Ramli Zefarina Zulkafli Geoffrey Keith Chambers Raja Sabrina Amani Raja Zilan2,4, and Hisham Atan Edinur |
| author_facet | Marini Ramli Zefarina Zulkafli Geoffrey Keith Chambers Raja Sabrina Amani Raja Zilan2,4, and Hisham Atan Edinur |
| author_sort | Marini Ramli |
| collection | DOAJ |
| description | Objectives: Blood bank centers routinely screen for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) to ensure the safety of blood supply and thus prevent the dissemination of these viruses via blood transfusion. We sought to evaluate the detection of transfusion-transmitted infection (TTI) markers using standard serological methods and nucleic acid testing (NAT) among blood donors in Hospital Universiti Sains Malaysia. Methods: Donated blood units were assessed for the presence or absence of HBV, HCV, and HIV using two screening method: serology and NAT. Reactive blood samples were then subjected to serological confirmatory and NAT discriminatory assays. Results: A total of 9669 donors were recruited from September 2017 to June 2018. Among these, 36 donors were reactive either for HBV, HCV, or HIV by serological testing and eight by NAT screening. However, only 10 (three for HBV and seven for HCV) donors tested positive using serological testing and five (two for HBV and three for HCV) by NAT discriminatory assays. Note that all five NAT positive donors detected in the NAT discriminatory assays were confirmed to be serologically reactive. Therefore, the prevalence of HBV, HCV, and HIV was 0.03%, 0.1%, and 0.0%, respectively, in our donor pool. Conclusions: Both serological and NAT screening and confirmatory assays should be used routinely to reduce the risk of infection transmission via the transfusion of blood and blood components. |
| first_indexed | 2024-12-22T04:23:13Z |
| format | Article |
| id | doaj.art-fe94939a59ba45b2a77d673c83efeeae |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-22T04:23:13Z |
| publishDate | 2020-11-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-fe94939a59ba45b2a77d673c83efeeae2022-12-21T18:39:14ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042020-11-01356e189e18910.5001/omj.2020.86The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains MalaysiaMarini Ramli0Zefarina Zulkafli1Geoffrey Keith Chambers2Raja Sabrina Amani Raja Zilan2,4, and 3Hisham Atan Edinur4School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia; Transfusion Medicine Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, MalaysiaSchool of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia; Transfusion Medicine Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, MalaysiaSchool of Biological Sciences, Victoria University of Wellington, Wellington, New ZealandTransfusion Medicine Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, Malaysia; School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, MalaysiaTransfusion Medicine Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, Malaysia; School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, MalaysiaObjectives: Blood bank centers routinely screen for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) to ensure the safety of blood supply and thus prevent the dissemination of these viruses via blood transfusion. We sought to evaluate the detection of transfusion-transmitted infection (TTI) markers using standard serological methods and nucleic acid testing (NAT) among blood donors in Hospital Universiti Sains Malaysia. Methods: Donated blood units were assessed for the presence or absence of HBV, HCV, and HIV using two screening method: serology and NAT. Reactive blood samples were then subjected to serological confirmatory and NAT discriminatory assays. Results: A total of 9669 donors were recruited from September 2017 to June 2018. Among these, 36 donors were reactive either for HBV, HCV, or HIV by serological testing and eight by NAT screening. However, only 10 (three for HBV and seven for HCV) donors tested positive using serological testing and five (two for HBV and three for HCV) by NAT discriminatory assays. Note that all five NAT positive donors detected in the NAT discriminatory assays were confirmed to be serologically reactive. Therefore, the prevalence of HBV, HCV, and HIV was 0.03%, 0.1%, and 0.0%, respectively, in our donor pool. Conclusions: Both serological and NAT screening and confirmatory assays should be used routinely to reduce the risk of infection transmission via the transfusion of blood and blood components.http://omjournal.org/articleDetails.aspx?coType=1&aId=2776hepatitis b virusblood donorsblood banksmalaysiahiv infectionstransfusion reactionblood transfusionhepatitis c |
| spellingShingle | Marini Ramli Zefarina Zulkafli Geoffrey Keith Chambers Raja Sabrina Amani Raja Zilan2,4, and Hisham Atan Edinur The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia Oman Medical Journal hepatitis b virus blood donors blood banks malaysia hiv infections transfusion reaction blood transfusion hepatitis c |
| title | The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia |
| title_full | The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia |
| title_fullStr | The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia |
| title_full_unstemmed | The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia |
| title_short | The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia |
| title_sort | prevalence of transfusion transmitted infections among blood donors in hospital universiti sains malaysia |
| topic | hepatitis b virus blood donors blood banks malaysia hiv infections transfusion reaction blood transfusion hepatitis c |
| url | http://omjournal.org/articleDetails.aspx?coType=1&aId=2776 |
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