Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report

Abstract Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by the infiltration of blood and bone marrow by immature monocytes, in which extra‐hematopoietic localization is uncommon. We report the case of a 69‐year‐old‐man with highly likely ectopic...

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Main Authors: Clémence Haméon, Antoine Machet, Laurianne Drieu La Rochelle, Nicolas Vallet, Julien Lejeune, Noémie Ravalet, Jean‐Philippe Cottier, Olivier Hérault, Emmanuel Gyan
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:eJHaem
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Online Access:https://doi.org/10.1002/jha2.740
Description
Summary:Abstract Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by the infiltration of blood and bone marrow by immature monocytes, in which extra‐hematopoietic localization is uncommon. We report the case of a 69‐year‐old‐man with highly likely ectopic brain CMML involvement by MRI. Without the possibility of cerebral biopsy and with a negative infectious disease assessment, high‐dose cytarabine‐based chemotherapy was successfully administered. The favorable evolution in this case highlights the potential benefit of such treatment, even without a cerebral biopsy to confirm the disease. This case can aid clinical decision‐making in the future.
ISSN:2688-6146