Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report
Abstract Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by the infiltration of blood and bone marrow by immature monocytes, in which extra‐hematopoietic localization is uncommon. We report the case of a 69‐year‐old‐man with highly likely ectopic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.740 |
| _version_ | 1797685650379505664 |
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| author | Clémence Haméon Antoine Machet Laurianne Drieu La Rochelle Nicolas Vallet Julien Lejeune Noémie Ravalet Jean‐Philippe Cottier Olivier Hérault Emmanuel Gyan |
| author_facet | Clémence Haméon Antoine Machet Laurianne Drieu La Rochelle Nicolas Vallet Julien Lejeune Noémie Ravalet Jean‐Philippe Cottier Olivier Hérault Emmanuel Gyan |
| author_sort | Clémence Haméon |
| collection | DOAJ |
| description | Abstract Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by the infiltration of blood and bone marrow by immature monocytes, in which extra‐hematopoietic localization is uncommon. We report the case of a 69‐year‐old‐man with highly likely ectopic brain CMML involvement by MRI. Without the possibility of cerebral biopsy and with a negative infectious disease assessment, high‐dose cytarabine‐based chemotherapy was successfully administered. The favorable evolution in this case highlights the potential benefit of such treatment, even without a cerebral biopsy to confirm the disease. This case can aid clinical decision‐making in the future. |
| first_indexed | 2024-03-12T00:47:41Z |
| format | Article |
| id | doaj.art-fe94f03cc55445a49d5f139424876be5 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T00:47:41Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-fe94f03cc55445a49d5f139424876be52023-09-14T15:30:48ZengWileyeJHaem2688-61462023-08-014384484710.1002/jha2.740Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case reportClémence Haméon0Antoine Machet1Laurianne Drieu La Rochelle2Nicolas Vallet3Julien Lejeune4Noémie Ravalet5Jean‐Philippe Cottier6Olivier Hérault7Emmanuel Gyan8Hematology and Cell Therapy Department Tours University Hospital Tours FranceHematology and Cell Therapy Department Tours University Hospital Tours FranceHematology and Cell Therapy Department Tours University Hospital Tours FranceHematology and Cell Therapy Department Tours University Hospital Tours FranceHematology and Cell Therapy Department Tours University Hospital Tours FranceDepartment of Biological Hematology Tours University Hospital Tours FranceNeuroradiology Department Tours University Hospital Tours FranceDepartment of Biological Hematology Tours University Hospital Tours FranceHematology and Cell Therapy Department Tours University Hospital Tours FranceAbstract Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by the infiltration of blood and bone marrow by immature monocytes, in which extra‐hematopoietic localization is uncommon. We report the case of a 69‐year‐old‐man with highly likely ectopic brain CMML involvement by MRI. Without the possibility of cerebral biopsy and with a negative infectious disease assessment, high‐dose cytarabine‐based chemotherapy was successfully administered. The favorable evolution in this case highlights the potential benefit of such treatment, even without a cerebral biopsy to confirm the disease. This case can aid clinical decision‐making in the future.https://doi.org/10.1002/jha2.740case reportcerebral localizationchronic myelomonocytic leukemia |
| spellingShingle | Clémence Haméon Antoine Machet Laurianne Drieu La Rochelle Nicolas Vallet Julien Lejeune Noémie Ravalet Jean‐Philippe Cottier Olivier Hérault Emmanuel Gyan Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report eJHaem case report cerebral localization chronic myelomonocytic leukemia |
| title | Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report |
| title_full | Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report |
| title_fullStr | Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report |
| title_full_unstemmed | Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report |
| title_short | Cerebral localization of chronic myelomonocytic leukemia and improvement with high‐dose cytarabine: A case report |
| title_sort | cerebral localization of chronic myelomonocytic leukemia and improvement with high dose cytarabine a case report |
| topic | case report cerebral localization chronic myelomonocytic leukemia |
| url | https://doi.org/10.1002/jha2.740 |
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