Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations
From a study of 28 human populations, linkage disequilibrium (LD) between ABO and Rh blood group loci in human genome were estimated using two different statistic of population genetics viz. D and Q. In general, the haplotypes iRh+ and iRh- were, on average, 2 to 3-fold and 1.1 to 1.8-fold more freq...
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| Format: | Article |
| Language: | English |
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Society of Land Measurements and Cadastre from Transylvania (SMTCT)
2011-05-01
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| Series: | Notulae Scientia Biologicae |
| Online Access: | http://notulaebiologicae.ro/index.php/nsb/article/view/6042 |
| _version_ | 1811343391340888064 |
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| author | Supriyo CHAKRABORTY Alison MOTSINGER-REIF |
| author_facet | Supriyo CHAKRABORTY Alison MOTSINGER-REIF |
| author_sort | Supriyo CHAKRABORTY |
| collection | DOAJ |
| description | From a study of 28 human populations, linkage disequilibrium (LD) between ABO and Rh blood group loci in human genome were estimated using two different statistic of population genetics viz. D and Q. In general, the haplotypes iRh+ and iRh- were, on average, 2 to 3-fold and 1.1 to 1.8-fold more frequent respectively than the corresponding expected haplotype frequency in the populations under study. Expected haplotype frequencies were calculated for each population assuming equal frequencies of alleles at ABO and Rh loci. The observed frequency of IARh+ haplotype was more or less close to the expected frequency (0.165). The haplotypes IARh-, IBRh+ and IBRh- were less frequent than expected in the populations. The D value for haplotype iRh+ was positive for all the populations suggesting preponderance of this haplotype and hence non-random association between ABO and Rh loci. Q is a single measure of LD and suitable for estimation of LD between loci having multiple alleles. Q value ranged from 2.18 (Finland) to 8.07 (Hongkong). High LD, indicated by high Q, between ABO and Rh loci was observed in the populations of Hongkong, BV Muslims, Saudi Arabia, BV Hindus, India and Iceland. But the populations of Finland, Austria, Estonia, Poland and Israel showed low LD revealed by low Q between ABO and Rh loci. |
| first_indexed | 2024-04-13T19:28:31Z |
| format | Article |
| id | doaj.art-fe97b048325a49f3ae15c7f00feb0780 |
| institution | Directory Open Access Journal |
| issn | 2067-3205 2067-3264 |
| language | English |
| last_indexed | 2024-04-13T19:28:31Z |
| publishDate | 2011-05-01 |
| publisher | Society of Land Measurements and Cadastre from Transylvania (SMTCT) |
| record_format | Article |
| series | Notulae Scientia Biologicae |
| spelling | doaj.art-fe97b048325a49f3ae15c7f00feb07802022-12-22T02:33:17ZengSociety of Land Measurements and Cadastre from Transylvania (SMTCT)Notulae Scientia Biologicae2067-32052067-32642011-05-013207115913Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic PopulationsSupriyo CHAKRABORTY0Alison MOTSINGER-REIF1318 Ricks Hall, Bioinformatics Research Centre, North Carolina State University, Raleigh, NC 27695-7566, USABioinformatics Research Centre, North Carolina State University, Raleigh, NC 27695From a study of 28 human populations, linkage disequilibrium (LD) between ABO and Rh blood group loci in human genome were estimated using two different statistic of population genetics viz. D and Q. In general, the haplotypes iRh+ and iRh- were, on average, 2 to 3-fold and 1.1 to 1.8-fold more frequent respectively than the corresponding expected haplotype frequency in the populations under study. Expected haplotype frequencies were calculated for each population assuming equal frequencies of alleles at ABO and Rh loci. The observed frequency of IARh+ haplotype was more or less close to the expected frequency (0.165). The haplotypes IARh-, IBRh+ and IBRh- were less frequent than expected in the populations. The D value for haplotype iRh+ was positive for all the populations suggesting preponderance of this haplotype and hence non-random association between ABO and Rh loci. Q is a single measure of LD and suitable for estimation of LD between loci having multiple alleles. Q value ranged from 2.18 (Finland) to 8.07 (Hongkong). High LD, indicated by high Q, between ABO and Rh loci was observed in the populations of Hongkong, BV Muslims, Saudi Arabia, BV Hindus, India and Iceland. But the populations of Finland, Austria, Estonia, Poland and Israel showed low LD revealed by low Q between ABO and Rh loci.http://notulaebiologicae.ro/index.php/nsb/article/view/6042 |
| spellingShingle | Supriyo CHAKRABORTY Alison MOTSINGER-REIF Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations Notulae Scientia Biologicae |
| title | Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations |
| title_full | Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations |
| title_fullStr | Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations |
| title_full_unstemmed | Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations |
| title_short | Linkage Disequilibrium between ABO and Rh Loci in Barak Valley Populations vis-�-vis a Few Exotic Populations |
| title_sort | linkage disequilibrium between abo and rh loci in barak valley populations vis � vis a few exotic populations |
| url | http://notulaebiologicae.ro/index.php/nsb/article/view/6042 |
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