Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the acquisition of t(9;22) generating the fusion tyrosine kinase BCR::ABL1. However, despite the crucial role of this protein in the dysregulation of numerous signal transduction pathways, a direct measure of BCR::ABL1 kinase a...

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Bibliographic Details
Main Authors: Christian Boni, Massimiliano Bonifacio, Marzia Vezzalini, Luigi Scaffidi, Luisa Tomasello, Laurie L. Parker, Diego Boscarino, Dino Paladin, Mauro Krampera, Claudio Sorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
chronic myelogenous leukemia
acute lymphocytic leukemia
philadelphia chromosome
Bcr Abl
tyrosine kinase
imatinib (Gleevec)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.904510/full

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