Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration
Glioblastoma multiforme (GBM) is one of the most common aggressive, resistant, and invasive primary brain tumors that share neurodegenerative actions, resembling many neurodegenerative diseases. Although multiple conventional approaches, including chemoradiation, are more frequent in GBM therapy, th...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/11/1153 |
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| author | Sarmistha Mitra Raju Dash Yeasmin Akter Munni Nusrat Jahan Selsi Nasrin Akter Md Nazim Uddin Kishor Mazumder Il Soo Moon |
| author_facet | Sarmistha Mitra Raju Dash Yeasmin Akter Munni Nusrat Jahan Selsi Nasrin Akter Md Nazim Uddin Kishor Mazumder Il Soo Moon |
| author_sort | Sarmistha Mitra |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is one of the most common aggressive, resistant, and invasive primary brain tumors that share neurodegenerative actions, resembling many neurodegenerative diseases. Although multiple conventional approaches, including chemoradiation, are more frequent in GBM therapy, these approaches are ineffective in extending the mean survival rate and are associated with various side effects, including neurodegeneration. This review proposes an alternative strategy for managing GBM and neurodegeneration by targeting heat shock protein 90 (Hsp90). Hsp90 is a well-known molecular chaperone that plays essential roles in maintaining and stabilizing protein folding to degradation in protein homeostasis and modulates signaling in cancer and neurodegeneration by regulating many client protein substrates. The therapeutic benefits of Hsp90 inhibition are well-known for several malignancies, and recent evidence highlights that Hsp90 inhibitors potentially inhibit the aggressiveness of GBM, increasing the sensitivity of conventional treatment and providing neuroprotection in various neurodegenerative diseases. Herein, the overview of Hsp90 modulation in GBM and neurodegeneration progress has been discussed with a summary of recent outcomes on Hsp90 inhibition in various GBM models and neurodegeneration. Particular emphasis is also given to natural Hsp90 inhibitors that have been evidenced to show dual protection in both GBM and neurodegeneration. |
| first_indexed | 2024-03-09T18:09:29Z |
| format | Article |
| id | doaj.art-fe987d7a383c42b1bd2ba24a46cf004e |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T18:09:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-fe987d7a383c42b1bd2ba24a46cf004e2023-11-24T09:13:55ZengMDPI AGMetabolites2218-19892022-11-011211115310.3390/metabo12111153Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and NeurodegenerationSarmistha Mitra0Raju Dash1Yeasmin Akter Munni2Nusrat Jahan Selsi3Nasrin Akter4Md Nazim Uddin5Kishor Mazumder6Il Soo Moon7Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of KoreaDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of KoreaDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of KoreaProduct Development Department, Popular Pharmaceuticals Ltd., Dhaka 1207, BangladeshDepartment of Clinical Pharmacy and Molecular Pharmacology, East West University Bangladesh, Dhaka 1212, BangladeshDepartment of Pharmacy, Southern University Bangladesh, Chittagong 4000, BangladeshDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of KoreaGlioblastoma multiforme (GBM) is one of the most common aggressive, resistant, and invasive primary brain tumors that share neurodegenerative actions, resembling many neurodegenerative diseases. Although multiple conventional approaches, including chemoradiation, are more frequent in GBM therapy, these approaches are ineffective in extending the mean survival rate and are associated with various side effects, including neurodegeneration. This review proposes an alternative strategy for managing GBM and neurodegeneration by targeting heat shock protein 90 (Hsp90). Hsp90 is a well-known molecular chaperone that plays essential roles in maintaining and stabilizing protein folding to degradation in protein homeostasis and modulates signaling in cancer and neurodegeneration by regulating many client protein substrates. The therapeutic benefits of Hsp90 inhibition are well-known for several malignancies, and recent evidence highlights that Hsp90 inhibitors potentially inhibit the aggressiveness of GBM, increasing the sensitivity of conventional treatment and providing neuroprotection in various neurodegenerative diseases. Herein, the overview of Hsp90 modulation in GBM and neurodegeneration progress has been discussed with a summary of recent outcomes on Hsp90 inhibition in various GBM models and neurodegeneration. Particular emphasis is also given to natural Hsp90 inhibitors that have been evidenced to show dual protection in both GBM and neurodegeneration.https://www.mdpi.com/2218-1989/12/11/1153Hsp90glioblastomaneurodegenerationschemosensitivity |
| spellingShingle | Sarmistha Mitra Raju Dash Yeasmin Akter Munni Nusrat Jahan Selsi Nasrin Akter Md Nazim Uddin Kishor Mazumder Il Soo Moon Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration Metabolites Hsp90 glioblastoma neurodegenerations chemosensitivity |
| title | Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration |
| title_full | Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration |
| title_fullStr | Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration |
| title_full_unstemmed | Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration |
| title_short | Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration |
| title_sort | natural products targeting hsp90 for a concurrent strategy in glioblastoma and neurodegeneration |
| topic | Hsp90 glioblastoma neurodegenerations chemosensitivity |
| url | https://www.mdpi.com/2218-1989/12/11/1153 |
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