Internalized Amyloid-β (1-42) Peptide Inhibits the Store-Operated Calcium Entry in HT-22 Cells

Internalized Amyloid-β (1-42) Peptide Inhibits the Store-Operated Calcium Entry in HT-22 Cells

Dysregulation in calcium signaling pathways plays a major role in the initiation of Alzheimer’s disease (AD) pathogenesis. Accumulative experimental evidence obtained with cellular and animal models, as well as with AD brain samples, points out the high cytotoxicity of soluble small oligomeric forms...

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Bibliographic Details
Main Authors: Joana Poejo, Yolanda Orantos-Aguilera, Francisco Javier Martin-Romero, Ana Maria Mata, Carlos Gutierrez-Merino
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid-β(1-42)
store-operated calcium entry
STIM1
calmodulin
endoplasmic reticulum
HT-22 cells
Online Access:https://www.mdpi.com/1422-0067/23/20/12678

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