Iodine-mediated hydration of alkynes on keto-functionalized scaffolds: mechanistic insight and the regiospecific hydration of internal alkynes

An iodine-mediated hydration reaction of alkynes serves as a green alternative to metal-catalyzed procedures. Previous work has shown that this method works well with terminal alkynes on keto-functionalized scaffolds, including 1,3-dicarbonyls and their heteroatom analogues. It was hypothesized that...

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Bibliographic Details
Main Authors: Zachary Lee, Brandon R. Jones, Nyochembeng Nkengbeza, Michael Phillips, Kayla Valentine, Alexis Stewart, Brandon Sellers, Nicholas Shuber, Karelle S. Aiken
Format: Article
Language:English
Published: Beilstein-Institut 2019-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.15.265