Advances in BK Virus Complications in Organ Transplantation and Beyond
Reactivation of BK virus (BKV) remains a dreaded complication in immunosuppressed states. Conventionally, BKV is known as a cause for BKV-associated nephropathy and allograft dysfunction in kidney transplant recipients. However, emerging studies have shown its negative impact on native kidney functi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Kidney Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059520302053 |
| _version_ | 1818728657809571840 |
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| author | Abraham Cohen-Bucay Silvia E. Ramirez-Andrade Craig E. Gordon Jean M. Francis Vipul C. Chitalia |
| author_facet | Abraham Cohen-Bucay Silvia E. Ramirez-Andrade Craig E. Gordon Jean M. Francis Vipul C. Chitalia |
| author_sort | Abraham Cohen-Bucay |
| collection | DOAJ |
| description | Reactivation of BK virus (BKV) remains a dreaded complication in immunosuppressed states. Conventionally, BKV is known as a cause for BKV-associated nephropathy and allograft dysfunction in kidney transplant recipients. However, emerging studies have shown its negative impact on native kidney function and patient survival in other transplants and its potential role in diseases such as cancer. Because BKV-associated nephropathy is driven by immunosuppression, reduction in the latter is a convenient standard of care. However, this strategy is risk prone due to the development of donor-specific antibodies affecting long-term allograft survival. Despite its pathogenic role, there is a distinct lack of effective anti-BKV therapeutics. This limitation combined with increased morbidity and health care cost of BKV-associated diseases add to the complexity of BKV management. While summarizing recent advances in the pathogenesis of BKV-associated nephropathy and its reactivation in other organ transplants, this review illustrates the limitations of current and emerging therapeutic options and provides a compelling argument for an effective targeted anti-BKV drug. |
| first_indexed | 2024-12-17T22:33:29Z |
| format | Article |
| id | doaj.art-fe9abad0340a4ecb8d972beaad88bec2 |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-12-17T22:33:29Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-fe9abad0340a4ecb8d972beaad88bec22022-12-21T21:30:08ZengElsevierKidney Medicine2590-05952020-11-0126771786Advances in BK Virus Complications in Organ Transplantation and BeyondAbraham Cohen-Bucay0Silvia E. Ramirez-Andrade1Craig E. Gordon2Jean M. Francis3Vipul C. Chitalia4Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico; Nephrology Department, American British Cowdray Medical Center, Mexico City, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, MexicoDivision of Nephrology, Tufts Medical Center, Boston, MASection of Nephrology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; Renal Section, Boston University Medical Center, Boston, MARenal Section, Boston University Medical Center, Boston, MA; Institute of Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA; Veteran Affairs Boston Healthcare System, Boston, MA; Address for Correspondence: Vipul Chitalia, MD, PhD, Department of Medicine, EBRX X-540, Boston University Medical Center, 650 Albany St, 5th Fl, Boston, MA 02118.Reactivation of BK virus (BKV) remains a dreaded complication in immunosuppressed states. Conventionally, BKV is known as a cause for BKV-associated nephropathy and allograft dysfunction in kidney transplant recipients. However, emerging studies have shown its negative impact on native kidney function and patient survival in other transplants and its potential role in diseases such as cancer. Because BKV-associated nephropathy is driven by immunosuppression, reduction in the latter is a convenient standard of care. However, this strategy is risk prone due to the development of donor-specific antibodies affecting long-term allograft survival. Despite its pathogenic role, there is a distinct lack of effective anti-BKV therapeutics. This limitation combined with increased morbidity and health care cost of BKV-associated diseases add to the complexity of BKV management. While summarizing recent advances in the pathogenesis of BKV-associated nephropathy and its reactivation in other organ transplants, this review illustrates the limitations of current and emerging therapeutic options and provides a compelling argument for an effective targeted anti-BKV drug.http://www.sciencedirect.com/science/article/pii/S2590059520302053BK virus, transplantation |
| spellingShingle | Abraham Cohen-Bucay Silvia E. Ramirez-Andrade Craig E. Gordon Jean M. Francis Vipul C. Chitalia Advances in BK Virus Complications in Organ Transplantation and Beyond Kidney Medicine BK virus, transplantation |
| title | Advances in BK Virus Complications in Organ Transplantation and Beyond |
| title_full | Advances in BK Virus Complications in Organ Transplantation and Beyond |
| title_fullStr | Advances in BK Virus Complications in Organ Transplantation and Beyond |
| title_full_unstemmed | Advances in BK Virus Complications in Organ Transplantation and Beyond |
| title_short | Advances in BK Virus Complications in Organ Transplantation and Beyond |
| title_sort | advances in bk virus complications in organ transplantation and beyond |
| topic | BK virus, transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2590059520302053 |
| work_keys_str_mv | AT abrahamcohenbucay advancesinbkviruscomplicationsinorgantransplantationandbeyond AT silviaeramirezandrade advancesinbkviruscomplicationsinorgantransplantationandbeyond AT craigegordon advancesinbkviruscomplicationsinorgantransplantationandbeyond AT jeanmfrancis advancesinbkviruscomplicationsinorgantransplantationandbeyond AT vipulcchitalia advancesinbkviruscomplicationsinorgantransplantationandbeyond |