Osteopontin Is Associated with Multiple Sclerosis Relapses
Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease course. Osteopontin is also likely involved in...
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/178 |
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| author | Mario Stampanoni Bassi Fabio Buttari Luana Gilio Ennio Iezzi Giovanni Galifi Fortunata Carbone Teresa Micillo Ettore Dolcetti Federica Azzolini Antonio Bruno Angela Borrelli Georgia Mandolesi Valentina Rovella Marianna Storto Annamaria Finardi Roberto Furlan Diego Centonze Giuseppe Matarese |
| author_facet | Mario Stampanoni Bassi Fabio Buttari Luana Gilio Ennio Iezzi Giovanni Galifi Fortunata Carbone Teresa Micillo Ettore Dolcetti Federica Azzolini Antonio Bruno Angela Borrelli Georgia Mandolesi Valentina Rovella Marianna Storto Annamaria Finardi Roberto Furlan Diego Centonze Giuseppe Matarese |
| author_sort | Mario Stampanoni Bassi |
| collection | DOAJ |
| description | Background: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease course. Osteopontin is also likely involved in acute MS relapses. Methods: In 47 patients with relapsing-remitting MS, we explored the correlation between the time elapsed between the last clinical relapse and lumbar puncture, and the cerebrospinal fluid (CSF) levels of osteopontin and a group of inflammatory cytokines and adipokines such as resistin, plasminogen activator inhibitor-1, osteoprotegerin, interleukin (IL)-1β, IL-2, IL-6 and IL-1 receptor antagonist (IL-1ra). We also analyzed the correlations between CSF levels of osteopontin and the other CSF molecules considered. Results: Osteopontin CSF concentrations were higher in patients with a shorter time interval between the last clinical relapse and CSF withdrawal. In addition, CSF levels of osteopontin were positively correlated with the proinflammatory cytokines IL-2 and IL-6 and negatively correlated with the anti-inflammatory molecule IL-1ra. Conclusions: Our results further suggest the role of osteopontin in acute MS relapses showing that, in proximity to relapses, osteopontin expression in CSF may be increased along with other proinflammatory mediators and correlated with decreased concentrations of anti-inflammatory molecules. |
| first_indexed | 2024-03-09T13:29:46Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:29:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fe9e75357b304c719668b008e4ebe7e62023-11-30T21:20:36ZengMDPI AGBiomedicines2227-90592023-01-0111117810.3390/biomedicines11010178Osteopontin Is Associated with Multiple Sclerosis RelapsesMario Stampanoni Bassi0Fabio Buttari1Luana Gilio2Ennio Iezzi3Giovanni Galifi4Fortunata Carbone5Teresa Micillo6Ettore Dolcetti7Federica Azzolini8Antonio Bruno9Angela Borrelli10Georgia Mandolesi11Valentina Rovella12Marianna Storto13Annamaria Finardi14Roberto Furlan15Diego Centonze16Giuseppe Matarese17IRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyNeuroimmunology Unit, IRCCS Fondazione Santa Lucia, 00179 Rome, ItalyTreg Cell Lab, Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalySynaptic Immunopathology Lab, IRCCS San Raffaele, 00163 Rome, ItalyDepartment of Systems Medicine, Tor Vergata University, 00133 Rome, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, ItalyClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyLaboratory of Immunology, Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, ItalyBackground: Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration in multiple sclerosis (MS), promoting a worse disease course. Osteopontin is also likely involved in acute MS relapses. Methods: In 47 patients with relapsing-remitting MS, we explored the correlation between the time elapsed between the last clinical relapse and lumbar puncture, and the cerebrospinal fluid (CSF) levels of osteopontin and a group of inflammatory cytokines and adipokines such as resistin, plasminogen activator inhibitor-1, osteoprotegerin, interleukin (IL)-1β, IL-2, IL-6 and IL-1 receptor antagonist (IL-1ra). We also analyzed the correlations between CSF levels of osteopontin and the other CSF molecules considered. Results: Osteopontin CSF concentrations were higher in patients with a shorter time interval between the last clinical relapse and CSF withdrawal. In addition, CSF levels of osteopontin were positively correlated with the proinflammatory cytokines IL-2 and IL-6 and negatively correlated with the anti-inflammatory molecule IL-1ra. Conclusions: Our results further suggest the role of osteopontin in acute MS relapses showing that, in proximity to relapses, osteopontin expression in CSF may be increased along with other proinflammatory mediators and correlated with decreased concentrations of anti-inflammatory molecules.https://www.mdpi.com/2227-9059/11/1/178osteopontinmultiple sclerosiscytokinesinflammationIL-6relapses |
| spellingShingle | Mario Stampanoni Bassi Fabio Buttari Luana Gilio Ennio Iezzi Giovanni Galifi Fortunata Carbone Teresa Micillo Ettore Dolcetti Federica Azzolini Antonio Bruno Angela Borrelli Georgia Mandolesi Valentina Rovella Marianna Storto Annamaria Finardi Roberto Furlan Diego Centonze Giuseppe Matarese Osteopontin Is Associated with Multiple Sclerosis Relapses Biomedicines osteopontin multiple sclerosis cytokines inflammation IL-6 relapses |
| title | Osteopontin Is Associated with Multiple Sclerosis Relapses |
| title_full | Osteopontin Is Associated with Multiple Sclerosis Relapses |
| title_fullStr | Osteopontin Is Associated with Multiple Sclerosis Relapses |
| title_full_unstemmed | Osteopontin Is Associated with Multiple Sclerosis Relapses |
| title_short | Osteopontin Is Associated with Multiple Sclerosis Relapses |
| title_sort | osteopontin is associated with multiple sclerosis relapses |
| topic | osteopontin multiple sclerosis cytokines inflammation IL-6 relapses |
| url | https://www.mdpi.com/2227-9059/11/1/178 |
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