PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy

PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy

Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it has been found in fibrotic regions co-localiz...

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Bibliographic Details
Main Authors: Andrea Farini, Chiara Villa, Dario Di Silvestre, Pamela Bella, Luana Tripodi, Rossana Rossi, Clementina Sitzia, Stefano Gatti, Pierluigi Mauri, Yvan Torrente
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
Duchenne muscular dystrophy (DMD)
muscular dystrophy
cardiomyopathy
pentraxin 3 (PTX3)
alarmins
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00403/full

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