AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity

AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity

Dendritic cells (DCs) must integrate a broad array of environmental cues to exact control over downstream immune responses including TH polarization. The multienzyme aminoacyl-tRNA synthetase complex component AIMp1/p43 responds to cellular stress and exerts pro-inflammatory functions; however, a ro...

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Bibliographic Details
Main Authors: Dan Liang, Lin Tian, Ran You, Matthew M. Halpert, Vanaja Konduri, Yunyu C. Baig, Silke Paust, Doyeun Kim, Sunghoon Kim, Fuli Jia, Shixia Huang, Xiang Zhang, Farrah Kheradmand, David B. Corry, Brian E. Gilbert, Jonathan M. Levitt, William K. Decker
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
AIMp1
TH1 immunity
IL-12
antitumor immunity
antiviral immunity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01801/full

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