Comparison of Lethal and Nonlethal Mouse Models of <i>Orientia tsutsugamushi</i> Infection Reveals T-Cell Population-Associated Cytokine Signatures Correlated with Lethality and Protection

Comparison of Lethal and Nonlethal Mouse Models of <i>Orientia tsutsugamushi</i> Infection Reveals T-Cell Population-Associated Cytokine Signatures Correlated with Lethality and Protection

The antigenic diversity of <i>Orientia tsutsugamushi</i> as well as the interstrain difference(s) associated with virulence in mice impose the necessity to dissect the host immune response. In this study we compared the host response in lethal and non-lethal murine models of <i>O....

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Bibliographic Details
Main Authors: Alison Luce-Fedrow, Suchismita Chattopadhyay, Teik-Chye Chan, Gregory Pearson, John B. Patton, Allen L. Richards
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Tropical Medicine and Infectious Disease
Subjects:
scrub typhus
<i>Orientia tsutsugamushi</i>
mouse model
T cells
cytokines
lethality
Online Access:https://www.mdpi.com/2414-6366/6/3/121

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