Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center
"nIntroduction: Infections in neutropenic patients are considered as major causes of mortality and emergence of drug resistant Gram positive bacterial infections are crucially important to be covered if indicated. Vancomycin is active against most Gram positive bacteria including methicilli...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2010-07-01
|
| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18604.pdf&manuscript_id=18604 |
| _version_ | 1827842995864469504 |
|---|---|
| author | Alireza Hayatshahi Mohammadreza Javadi Hassan Torkamandi Molouk Hadjibabaie Sara Alahyari Kheirollah Gholami Kamran Alimoghaddam Masoud Iravani Ardeshir Ghavamzadeh |
| author_facet | Alireza Hayatshahi Mohammadreza Javadi Hassan Torkamandi Molouk Hadjibabaie Sara Alahyari Kheirollah Gholami Kamran Alimoghaddam Masoud Iravani Ardeshir Ghavamzadeh |
| author_sort | Alireza Hayatshahi |
| collection | DOAJ |
| description | "nIntroduction: Infections in neutropenic patients are considered as major causes of mortality and emergence of drug resistant Gram positive bacterial infections are crucially important to be covered if indicated. Vancomycin is active against most Gram positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). In this study, we evaluated the appropriate utilization of this agent. "nMethods: We conducted a prospective observational study at bone marrow transplantation research center, Shariati teaching hospital in Tehran to evaluate the appropriateness of vancomycin utilization for our adult bone marrow transplantation (BMT) patients for a period of six months. "nResults: The charts of a total of 117 patients were prospectively reviewed in 3 adult BMT wards. Seventy four patients (63.2%) received vancomycin treatment during their hospital stay. Most patients received allogienic versus autologous transplantation (62.2%, 18.9%). Majority of patients were under 50 years of age (91.9%). About 58% of cases were febrile neutropenic at the time of vancomycin initiation. Based on the criteria of appropriate indications, vancomycin utilization was justified in 59.5% of cases which 43.2% of those cases received appropriate initial doses. "nConclusion: Based on the results of this study, in the majority of our BMT patients vancomycin was utilized appropriately as a part of their empiric treatment. More attention in the time of initiation and also dose adjustment seems to be necessary to minimize treatment failure and the emergence of drug resistance. |
| first_indexed | 2024-03-12T08:18:23Z |
| format | Article |
| id | doaj.art-fea2321d49fe4138aa262e5908b77bd2 |
| institution | Directory Open Access Journal |
| issn | 2008-3009 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:18:23Z |
| publishDate | 2010-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-fea2321d49fe4138aa262e5908b77bd22023-09-02T18:40:48ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072010-07-01431013Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation CenterAlireza HayatshahiMohammadreza JavadiHassan TorkamandiMolouk HadjibabaieSara AlahyariKheirollah GholamiKamran AlimoghaddamMasoud IravaniArdeshir Ghavamzadeh"nIntroduction: Infections in neutropenic patients are considered as major causes of mortality and emergence of drug resistant Gram positive bacterial infections are crucially important to be covered if indicated. Vancomycin is active against most Gram positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). In this study, we evaluated the appropriate utilization of this agent. "nMethods: We conducted a prospective observational study at bone marrow transplantation research center, Shariati teaching hospital in Tehran to evaluate the appropriateness of vancomycin utilization for our adult bone marrow transplantation (BMT) patients for a period of six months. "nResults: The charts of a total of 117 patients were prospectively reviewed in 3 adult BMT wards. Seventy four patients (63.2%) received vancomycin treatment during their hospital stay. Most patients received allogienic versus autologous transplantation (62.2%, 18.9%). Majority of patients were under 50 years of age (91.9%). About 58% of cases were febrile neutropenic at the time of vancomycin initiation. Based on the criteria of appropriate indications, vancomycin utilization was justified in 59.5% of cases which 43.2% of those cases received appropriate initial doses. "nConclusion: Based on the results of this study, in the majority of our BMT patients vancomycin was utilized appropriately as a part of their empiric treatment. More attention in the time of initiation and also dose adjustment seems to be necessary to minimize treatment failure and the emergence of drug resistance.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18604.pdf&manuscript_id=18604 VancomycinFebrile NeutropenicEmpiric TreatmentGram positive infection |
| spellingShingle | Alireza Hayatshahi Mohammadreza Javadi Hassan Torkamandi Molouk Hadjibabaie Sara Alahyari Kheirollah Gholami Kamran Alimoghaddam Masoud Iravani Ardeshir Ghavamzadeh Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center International Journal of Hematology-Oncology and Stem Cell Research Vancomycin Febrile Neutropenic Empiric Treatment Gram positive infection |
| title | Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center |
| title_full | Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center |
| title_fullStr | Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center |
| title_full_unstemmed | Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center |
| title_short | Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center |
| title_sort | drug utilization review of vancomycin in febrile neutropenic patients hospitalized at a bone marrow transplantation center |
| topic | Vancomycin Febrile Neutropenic Empiric Treatment Gram positive infection |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18604.pdf&manuscript_id=18604 |
| work_keys_str_mv | AT alirezahayatshahi drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT mohammadrezajavadi drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT hassantorkamandi drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT moloukhadjibabaie drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT saraalahyari drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT kheirollahgholami drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT kamranalimoghaddam drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT masoudiravani drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter AT ardeshirghavamzadeh drugutilizationreviewofvancomycininfebrileneutropenicpatientshospitalizedatabonemarrowtransplantationcenter |