The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia
Introduction: Extramedullary hematopoiesis (EMH) is one of the main complications in patients with thalassemia in compensation for the underlying ineffective erythropoiesis. This study aimed to evaluate the association between ineffective erythropoiesis biomarkers and EMH in patients with thalassem...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2022-06-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/4945 |
| _version_ | 1811324101981110272 |
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| author | Siriyakorn Chansai Supawadee Yamsri Supan Fucharoen Goonnapa Fucharoen Nattiya Teawtrakul |
| author_facet | Siriyakorn Chansai Supawadee Yamsri Supan Fucharoen Goonnapa Fucharoen Nattiya Teawtrakul |
| author_sort | Siriyakorn Chansai |
| collection | DOAJ |
| description |
Introduction: Extramedullary hematopoiesis (EMH) is one of the main complications in patients with thalassemia in compensation for the underlying ineffective erythropoiesis. This study aimed to evaluate the association between ineffective erythropoiesis biomarkers and EMH in patients with thalassemia.
Methods: A cross-sectional study of thalassemia patients aged >18 years old at Srinagarind Hospital was performed. Phosphatidylserine-exposed red blood cells (PS-exposed RBCs) were studied by flow cytometry. The levels of growth differentiation factor-15 (GDF15) and soluble transferrin receptor (sTfR) levels were determined using ELISA.
Results: One hundred and thirty-one patients were enrolled. EMH was found in 34 patients (26.0%). EMH was more prevalent among patients with β-thalassemia as compared to those with α-thalassemia (36.4% vs. 4.7%). The levels of GDF15 and sTfR were different between the two groups and indicated a greater degree of ineffective erythropoiesis in β-thalassemia patients. The levels of PS-exposed RBCs showed a modest correlation with EMH. Advanced age and the PS-exposed RBC levels had a statistical significance associated with EMH.
Conclusions: Advanced age and high PS-exposed RBC levels are associated with EMH in thalassemia. PS-exposed RBCs showed a modest correlation with EMH and may be used to predict the development of EMH in thalassemia.
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| first_indexed | 2024-04-13T14:08:18Z |
| format | Article |
| id | doaj.art-fea35046cb5146d4862ca39c25fe4b90 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-04-13T14:08:18Z |
| publishDate | 2022-06-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-fea35046cb5146d4862ca39c25fe4b902022-12-22T02:43:51ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062022-06-0114110.4084/MJHID.2022.052The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemiaSiriyakorn ChansaiSupawadee YamsriSupan FucharoenGoonnapa FucharoenNattiya Teawtrakul0Khon Kaen University Introduction: Extramedullary hematopoiesis (EMH) is one of the main complications in patients with thalassemia in compensation for the underlying ineffective erythropoiesis. This study aimed to evaluate the association between ineffective erythropoiesis biomarkers and EMH in patients with thalassemia. Methods: A cross-sectional study of thalassemia patients aged >18 years old at Srinagarind Hospital was performed. Phosphatidylserine-exposed red blood cells (PS-exposed RBCs) were studied by flow cytometry. The levels of growth differentiation factor-15 (GDF15) and soluble transferrin receptor (sTfR) levels were determined using ELISA. Results: One hundred and thirty-one patients were enrolled. EMH was found in 34 patients (26.0%). EMH was more prevalent among patients with β-thalassemia as compared to those with α-thalassemia (36.4% vs. 4.7%). The levels of GDF15 and sTfR were different between the two groups and indicated a greater degree of ineffective erythropoiesis in β-thalassemia patients. The levels of PS-exposed RBCs showed a modest correlation with EMH. Advanced age and the PS-exposed RBC levels had a statistical significance associated with EMH. Conclusions: Advanced age and high PS-exposed RBC levels are associated with EMH in thalassemia. PS-exposed RBCs showed a modest correlation with EMH and may be used to predict the development of EMH in thalassemia. https://www.mjhid.org/index.php/mjhid/article/view/4945Ineffective erythropoiesis biomarkers, thalassemia, extramedullary erythropoiesis |
| spellingShingle | Siriyakorn Chansai Supawadee Yamsri Supan Fucharoen Goonnapa Fucharoen Nattiya Teawtrakul The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia Mediterranean Journal of Hematology and Infectious Diseases Ineffective erythropoiesis biomarkers, thalassemia, extramedullary erythropoiesis |
| title | The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia |
| title_full | The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia |
| title_fullStr | The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia |
| title_full_unstemmed | The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia |
| title_short | The correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia |
| title_sort | correlation between ineffective erythropoiesis biomarkers and development of extramedullary hematopoiesis in patients with thalassemia |
| topic | Ineffective erythropoiesis biomarkers, thalassemia, extramedullary erythropoiesis |
| url | https://www.mjhid.org/index.php/mjhid/article/view/4945 |
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