Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteocla...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20807-8 |
| _version_ | 1818692196840243200 |
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| author | David E. Place R. K. Subbarao Malireddi Jieun Kim Peter Vogel Masahiro Yamamoto Thirumala-Devi Kanneganti |
| author_facet | David E. Place R. K. Subbarao Malireddi Jieun Kim Peter Vogel Masahiro Yamamoto Thirumala-Devi Kanneganti |
| author_sort | David E. Place |
| collection | DOAJ |
| description | The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteoclast functions. |
| first_indexed | 2024-12-17T12:53:57Z |
| format | Article |
| id | doaj.art-fea52b57d5b54778a319077014717dd0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:53:57Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fea52b57d5b54778a319077014717dd02022-12-21T21:47:32ZengNature PortfolioNature Communications2041-17232021-01-011211910.1038/s41467-020-20807-8Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteinsDavid E. Place0R. K. Subbarao Malireddi1Jieun Kim2Peter Vogel3Masahiro Yamamoto4Thirumala-Devi Kanneganti5Department of Immunology, St. Jude Children’s Research HospitalDepartment of Immunology, St. Jude Children’s Research HospitalCenter for In Vivo Imaging and Therapeutics, St. Jude Children’s Research HospitalVeterinary Pathology Core, St. Jude Children’s Research HospitalDepartment of Immunoparasitology, Osaka UniversityDepartment of Immunology, St. Jude Children’s Research HospitalThe innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteoclast functions.https://doi.org/10.1038/s41467-020-20807-8 |
| spellingShingle | David E. Place R. K. Subbarao Malireddi Jieun Kim Peter Vogel Masahiro Yamamoto Thirumala-Devi Kanneganti Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins Nature Communications |
| title | Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins |
| title_full | Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins |
| title_fullStr | Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins |
| title_full_unstemmed | Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins |
| title_short | Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins |
| title_sort | osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins |
| url | https://doi.org/10.1038/s41467-020-20807-8 |
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