Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses
Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and pr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/7/1142 |
| _version_ | 1797587342503968768 |
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| author | Yalan Liu Yuncheng Li Qinxue Hu |
| author_facet | Yalan Liu Yuncheng Li Qinxue Hu |
| author_sort | Yalan Liu |
| collection | DOAJ |
| description | Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses. |
| first_indexed | 2024-03-11T00:35:46Z |
| format | Article |
| id | doaj.art-fea56c0e53464712835ebda443bc715a |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T00:35:46Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fea56c0e53464712835ebda443bc715a2023-11-18T21:40:12ZengMDPI AGVaccines2076-393X2023-06-01117114210.3390/vaccines11071142Advances in saRNA Vaccine Research against Emerging/Re-Emerging VirusesYalan Liu0Yuncheng Li1Qinxue Hu2State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, ChinaState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, ChinaState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, ChinaAlthough conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses.https://www.mdpi.com/2076-393X/11/7/1142vaccineself-amplifying RNA (saRNA)emerging/re-emerging virus |
| spellingShingle | Yalan Liu Yuncheng Li Qinxue Hu Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses Vaccines vaccine self-amplifying RNA (saRNA) emerging/re-emerging virus |
| title | Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses |
| title_full | Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses |
| title_fullStr | Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses |
| title_full_unstemmed | Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses |
| title_short | Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses |
| title_sort | advances in sarna vaccine research against emerging re emerging viruses |
| topic | vaccine self-amplifying RNA (saRNA) emerging/re-emerging virus |
| url | https://www.mdpi.com/2076-393X/11/7/1142 |
| work_keys_str_mv | AT yalanliu advancesinsarnavaccineresearchagainstemergingreemergingviruses AT yunchengli advancesinsarnavaccineresearchagainstemergingreemergingviruses AT qinxuehu advancesinsarnavaccineresearchagainstemergingreemergingviruses |