Pregabalin in acute and chronic pain
Pregabalin is a gamma-amino-butyric acid analog shown to be effective in several models of neuropathic pain, incisional injury, and inflammatory injury. In this review, the role of pregabalin in acute postoperative pain and in chronic pain syndromes has been discussed. Multimodal perioperative analg...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
|
| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=3;spage=307;epage=314;aulast=Baidya |
| _version_ | 1828758761076948992 |
|---|---|
| author | Dalim Kumar Baidya Anil Agarwal Puneet Khanna Mahesh Kumar Arora |
| author_facet | Dalim Kumar Baidya Anil Agarwal Puneet Khanna Mahesh Kumar Arora |
| author_sort | Dalim Kumar Baidya |
| collection | DOAJ |
| description | Pregabalin is a gamma-amino-butyric acid analog shown to be effective in several models of neuropathic pain, incisional injury, and inflammatory injury. In this review, the role of pregabalin in acute postoperative pain and in chronic pain syndromes has been discussed. Multimodal perioperative analgesia with the use of gabapentinoids has become common. Based on available evidence from randomized controlled trials and meta-analysis, the perioperative administration of pregabalin reduces opioid consumption and opioid-related adverse effects in the first 24 h following surgery. Postoperative pain intensity is however not consistently reduced by pregabalin. Adverse effects like visual disturbance, sedation, dizziness, and headache are associated with higher doses. The advantage of the perioperative use of pregabalin is so far limited to laparoscopic, gynecological, and daycare surgeries which are not very painful. The role of the perioperative administration of pregabalin in preventing chronic pain following surgery, its efficacy in more painful surgeries and surgeries done under regional anesthesia, and the optimal dosage and duration of perioperative pregabalin need to be studied. The efficacy of pregabalin in chronic pain conditions like painful diabetic neuropathy, postherpetic neuralgia, central neuropathic pain, and fibromyalgia has been demonstrated. |
| first_indexed | 2024-12-11T00:47:06Z |
| format | Article |
| id | doaj.art-fea5d7eb5fbb44aeb56ee75e5b9db3bc |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-11T00:47:06Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-fea5d7eb5fbb44aeb56ee75e5b9db3bc2022-12-22T01:26:44ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852011-01-0127330731410.4103/0970-9185.83672Pregabalin in acute and chronic painDalim Kumar BaidyaAnil AgarwalPuneet KhannaMahesh Kumar AroraPregabalin is a gamma-amino-butyric acid analog shown to be effective in several models of neuropathic pain, incisional injury, and inflammatory injury. In this review, the role of pregabalin in acute postoperative pain and in chronic pain syndromes has been discussed. Multimodal perioperative analgesia with the use of gabapentinoids has become common. Based on available evidence from randomized controlled trials and meta-analysis, the perioperative administration of pregabalin reduces opioid consumption and opioid-related adverse effects in the first 24 h following surgery. Postoperative pain intensity is however not consistently reduced by pregabalin. Adverse effects like visual disturbance, sedation, dizziness, and headache are associated with higher doses. The advantage of the perioperative use of pregabalin is so far limited to laparoscopic, gynecological, and daycare surgeries which are not very painful. The role of the perioperative administration of pregabalin in preventing chronic pain following surgery, its efficacy in more painful surgeries and surgeries done under regional anesthesia, and the optimal dosage and duration of perioperative pregabalin need to be studied. The efficacy of pregabalin in chronic pain conditions like painful diabetic neuropathy, postherpetic neuralgia, central neuropathic pain, and fibromyalgia has been demonstrated.http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=3;spage=307;epage=314;aulast=BaidyaAcute perioperative painchronic pain syndromespregabalin |
| spellingShingle | Dalim Kumar Baidya Anil Agarwal Puneet Khanna Mahesh Kumar Arora Pregabalin in acute and chronic pain Journal of Anaesthesiology Clinical Pharmacology Acute perioperative pain chronic pain syndromes pregabalin |
| title | Pregabalin in acute and chronic pain |
| title_full | Pregabalin in acute and chronic pain |
| title_fullStr | Pregabalin in acute and chronic pain |
| title_full_unstemmed | Pregabalin in acute and chronic pain |
| title_short | Pregabalin in acute and chronic pain |
| title_sort | pregabalin in acute and chronic pain |
| topic | Acute perioperative pain chronic pain syndromes pregabalin |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=3;spage=307;epage=314;aulast=Baidya |
| work_keys_str_mv | AT dalimkumarbaidya pregabalininacuteandchronicpain AT anilagarwal pregabalininacuteandchronicpain AT puneetkhanna pregabalininacuteandchronicpain AT maheshkumararora pregabalininacuteandchronicpain |