Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells

Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells

Abstract Excessive reactive oxygen species (ROS) in nucleus pulposus cells (NPCs) promote extracellular matrix (ECM) degradation and cellular inflammatory responses by activating a variety of cellular pathways, ultimately inducing cell apoptosis and leading to the development of low back pain. Here,...

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Bibliographic Details
Main Authors: Hao Yu, Yun Teng, Jun Ge, Ming Yang, Haifeng Xie, Tianyi Wu, Qi Yan, Mengting Jia, Qing Zhu, Yanping Shen, Lianxue Zhang, Jun Zou
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Subjects:
Diselenide-containing nanoparticles
Reactive oxygen species (ROS)-responsive drug release
Isoginkgetin
Autophagy
Intervertebral disc degeneration
Online Access:https://doi.org/10.1186/s12951-023-01856-9

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