Resistance to thyrotropin: familial case report
Two female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Endocrinology Research Centre
2016-02-01
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| Series: | Клиническая и экспериментальная тиреоидология |
| Subjects: | |
| Online Access: | https://cet-endojournals.ru/ket/article/viewFile/7699/5652 |
| _version_ | 1823945531697659904 |
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| author | Mariya Aleksandrovna Osipovskaya Alexey Vasil'evich Kiyaev Nina Alekseevna Makretskaya Evgeny Viktorovich Vasiliev Anatoly Nikolaevich Tiulpakov |
| author_facet | Mariya Aleksandrovna Osipovskaya Alexey Vasil'evich Kiyaev Nina Alekseevna Makretskaya Evgeny Viktorovich Vasiliev Anatoly Nikolaevich Tiulpakov |
| author_sort | Mariya Aleksandrovna Osipovskaya |
| collection | DOAJ |
| description | Two female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed. |
| first_indexed | 2024-12-17T09:17:54Z |
| format | Article |
| id | doaj.art-fea80bbed7974e1eb6d93b9cd0cedc5e |
| institution | Directory Open Access Journal |
| issn | 1995-5472 2310-3787 |
| language | Russian |
| last_indexed | 2024-12-17T09:17:54Z |
| publishDate | 2016-02-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Клиническая и экспериментальная тиреоидология |
| spelling | doaj.art-fea80bbed7974e1eb6d93b9cd0cedc5e2022-12-21T21:54:53ZrusEndocrinology Research CentreКлиническая и экспериментальная тиреоидология1995-54722310-37872016-02-01114363910.14341/ket2015436-397340Resistance to thyrotropin: familial case reportMariya Aleksandrovna Osipovskaya0Alexey Vasil'evich Kiyaev1Nina Alekseevna Makretskaya2Evgeny Viktorovich Vasiliev3Anatoly Nikolaevich Tiulpakov4Ural State Medical UniversityUral State Medical UniversityEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreTwo female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed.https://cet-endojournals.ru/ket/article/viewFile/7699/5652subclinical hypothyroidismresistance to thyrotropintshrchildren |
| spellingShingle | Mariya Aleksandrovna Osipovskaya Alexey Vasil'evich Kiyaev Nina Alekseevna Makretskaya Evgeny Viktorovich Vasiliev Anatoly Nikolaevich Tiulpakov Resistance to thyrotropin: familial case report Клиническая и экспериментальная тиреоидология subclinical hypothyroidism resistance to thyrotropin tshr children |
| title | Resistance to thyrotropin: familial case report |
| title_full | Resistance to thyrotropin: familial case report |
| title_fullStr | Resistance to thyrotropin: familial case report |
| title_full_unstemmed | Resistance to thyrotropin: familial case report |
| title_short | Resistance to thyrotropin: familial case report |
| title_sort | resistance to thyrotropin familial case report |
| topic | subclinical hypothyroidism resistance to thyrotropin tshr children |
| url | https://cet-endojournals.ru/ket/article/viewFile/7699/5652 |
| work_keys_str_mv | AT mariyaaleksandrovnaosipovskaya resistancetothyrotropinfamilialcasereport AT alexeyvasilevichkiyaev resistancetothyrotropinfamilialcasereport AT ninaalekseevnamakretskaya resistancetothyrotropinfamilialcasereport AT evgenyviktorovichvasiliev resistancetothyrotropinfamilialcasereport AT anatolynikolaevichtiulpakov resistancetothyrotropinfamilialcasereport |