Resistance to thyrotropin: familial case report

Resistance to thyrotropin: familial case report

Two female dizygotic twins with subclinical primary hypothyroidism due to homozygous p.R450H mutation in TSHR gene are presented. A 5-year follow-up in both cases showed no progression of thyroid dysfunction. Indications for levothyroxine replacement in subclinical hypothyroidism are discussed.

Bibliographic Details
Main Authors: Mariya Aleksandrovna Osipovskaya, Alexey Vasil'evich Kiyaev, Nina Alekseevna Makretskaya, Evgeny Viktorovich Vasiliev, Anatoly Nikolaevich Tiulpakov
Format: Article
Language:Russian
Published: Endocrinology Research Centre 2016-02-01
Series:Клиническая и экспериментальная тиреоидология
Subjects:
subclinical hypothyroidism
resistance to thyrotropin
tshr
children
Online Access:https://cet-endojournals.ru/ket/article/viewFile/7699/5652

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