Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We prod...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/21/3703 |
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| author | Muhammad Umar Aslam Khan Saiful Izwan Abd Razaq Hassan Mehboob Sarish Rehman Wafa Shamsan Al-Arjan Rashid Amin |
| author_facet | Muhammad Umar Aslam Khan Saiful Izwan Abd Razaq Hassan Mehboob Sarish Rehman Wafa Shamsan Al-Arjan Rashid Amin |
| author_sort | Muhammad Umar Aslam Khan |
| collection | DOAJ |
| description | The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemocompatible. In vitro, silver sulfadiazine release profile in PBS solution was analyzed via the Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. The drug release kinetics was studied against different mathematical models (zero-order, first-order, Higuchi, Hixson–Crowell, Korsmeyer–Peppas, and Baker–Lonsdale models) and compared their regression coefficient (R<sup>2</sup>) values. It was observed that drug release follows the Baker–Lonsdale model, as it has the highest value (0.989) of R<sup>2</sup>. Hence, the obtained results indicated that, due to optimized swelling, wetting, and degradation, the blended composite hydrogel BCH-3 could be an essential wound dressing biomaterial for sustained drug release for skin wound care and treatment. |
| first_indexed | 2024-03-10T05:55:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T05:55:25Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-fea8c9185647418fb3663a4d384204b72023-11-22T21:27:28ZengMDPI AGPolymers2073-43602021-10-011321370310.3390/polym13213703Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug ReleaseMuhammad Umar Aslam Khan0Saiful Izwan Abd Razaq1Hassan Mehboob2Sarish Rehman3Wafa Shamsan Al-Arjan4Rashid Amin5BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, MalaysiaInstitute of Personalized Medicine, School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University (SJTU),1954 Huashan Road, Shanghai 200030, ChinaDepartment of Engineering Management, College of Engineering, Prince Sultan University, Rafha Street, P.O. Box 66833, Riyadh 11586, Saudi ArabiaChemistry Department, McGill University, 801 Sherbrooke St. W, Montreal, QC H3A0G4, CanadaDepartment of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biology, College of Sciences, University of Hafr Al Batin, Hafar Al-Batin 39524, Saudi ArabiaThe treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemocompatible. In vitro, silver sulfadiazine release profile in PBS solution was analyzed via the Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. The drug release kinetics was studied against different mathematical models (zero-order, first-order, Higuchi, Hixson–Crowell, Korsmeyer–Peppas, and Baker–Lonsdale models) and compared their regression coefficient (R<sup>2</sup>) values. It was observed that drug release follows the Baker–Lonsdale model, as it has the highest value (0.989) of R<sup>2</sup>. Hence, the obtained results indicated that, due to optimized swelling, wetting, and degradation, the blended composite hydrogel BCH-3 could be an essential wound dressing biomaterial for sustained drug release for skin wound care and treatment.https://www.mdpi.com/2073-4360/13/21/3703antibacterialbiomaterialsbiopolymerscontrolled drug releasehemocompatibilitykinetics studies |
| spellingShingle | Muhammad Umar Aslam Khan Saiful Izwan Abd Razaq Hassan Mehboob Sarish Rehman Wafa Shamsan Al-Arjan Rashid Amin Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release Polymers antibacterial biomaterials biopolymers controlled drug release hemocompatibility kinetics studies |
| title | Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release |
| title_full | Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release |
| title_fullStr | Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release |
| title_full_unstemmed | Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release |
| title_short | Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release |
| title_sort | antibacterial and hemocompatible ph responsive hydrogel for skin wound healing application in vitro drug release |
| topic | antibacterial biomaterials biopolymers controlled drug release hemocompatibility kinetics studies |
| url | https://www.mdpi.com/2073-4360/13/21/3703 |
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