The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
NLR family pyrin domain-containing 3 (NLRP3) is an intracellular protein that after recognizing a broad spectrum of stressors, such as microbial motifs and endogenous danger signals, promotes the activation and release of the pro-inflammatory cytokines IL-1β and IL-18, thus playing an essential role...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11845 |
| _version_ | 1797512398913929216 |
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| author | J. Luis Espinoza Kosuke Kamio Vu Quang Lam Akiyoshi Takami |
| author_facet | J. Luis Espinoza Kosuke Kamio Vu Quang Lam Akiyoshi Takami |
| author_sort | J. Luis Espinoza |
| collection | DOAJ |
| description | NLR family pyrin domain-containing 3 (NLRP3) is an intracellular protein that after recognizing a broad spectrum of stressors, such as microbial motifs and endogenous danger signals, promotes the activation and release of the pro-inflammatory cytokines IL-1β and IL-18, thus playing an essential role in the innate immune response. Several blood cell types, including macrophages, dendritic cells, and hematopoietic stem and progenitor cells (HSPCs), express NLRP3, where it has been implicated in various physiological and pathological processes. For example, NLRP3 participates in the development and expansion of HSPCs, and their release from bone marrow into the peripheral blood has been implicated in certain hematological disorders including various types of leukemia. In addition, accumulating evidence indicates that activation of NLRP3 plays a pivotal role in the development of transplant complications in patients receiving hematopoietic stem cell transplantation (HSCT) including graft versus host disease, severe infections, and transplant-related mortality. The majority of these complications are triggered by the severe tissue damage derived from the conditioning regimens utilized in HSCT which, in turn, activates NLRP3 and, ultimately, promotes the release of proinflammatory cytokines such as IL-1β and IL-18. Here, we summarize the implications of NLRP3 in HSCT with an emphasis on the involvement of this inflammasome component in transplant complications. |
| first_indexed | 2024-03-10T06:01:16Z |
| format | Article |
| id | doaj.art-fead04cbeb774ef09b53919b332f55fa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:16Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fead04cbeb774ef09b53919b332f55fa2023-11-22T20:58:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211184510.3390/ijms222111845The Impact of NLRP3 Activation on Hematopoietic Stem Cell TransplantationJ. Luis Espinoza0Kosuke Kamio1Vu Quang Lam2Akiyoshi Takami3Faculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, JapanFaculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, JapanDivision of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, JapanDivision of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, JapanNLR family pyrin domain-containing 3 (NLRP3) is an intracellular protein that after recognizing a broad spectrum of stressors, such as microbial motifs and endogenous danger signals, promotes the activation and release of the pro-inflammatory cytokines IL-1β and IL-18, thus playing an essential role in the innate immune response. Several blood cell types, including macrophages, dendritic cells, and hematopoietic stem and progenitor cells (HSPCs), express NLRP3, where it has been implicated in various physiological and pathological processes. For example, NLRP3 participates in the development and expansion of HSPCs, and their release from bone marrow into the peripheral blood has been implicated in certain hematological disorders including various types of leukemia. In addition, accumulating evidence indicates that activation of NLRP3 plays a pivotal role in the development of transplant complications in patients receiving hematopoietic stem cell transplantation (HSCT) including graft versus host disease, severe infections, and transplant-related mortality. The majority of these complications are triggered by the severe tissue damage derived from the conditioning regimens utilized in HSCT which, in turn, activates NLRP3 and, ultimately, promotes the release of proinflammatory cytokines such as IL-1β and IL-18. Here, we summarize the implications of NLRP3 in HSCT with an emphasis on the involvement of this inflammasome component in transplant complications.https://www.mdpi.com/1422-0067/22/21/11845inflammasomebone marrow transplantationtransplant related mortalityNLRP3 genotypestransplant outcomes |
| spellingShingle | J. Luis Espinoza Kosuke Kamio Vu Quang Lam Akiyoshi Takami The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation International Journal of Molecular Sciences inflammasome bone marrow transplantation transplant related mortality NLRP3 genotypes transplant outcomes |
| title | The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation |
| title_full | The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation |
| title_fullStr | The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation |
| title_full_unstemmed | The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation |
| title_short | The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation |
| title_sort | impact of nlrp3 activation on hematopoietic stem cell transplantation |
| topic | inflammasome bone marrow transplantation transplant related mortality NLRP3 genotypes transplant outcomes |
| url | https://www.mdpi.com/1422-0067/22/21/11845 |
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