Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future
The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/728 |
| _version_ | 1797625586539036672 |
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| author | Patrycja Ziętara Marta Dziewięcka Maria Augustyniak |
| author_facet | Patrycja Ziętara Marta Dziewięcka Maria Augustyniak |
| author_sort | Patrycja Ziętara |
| collection | DOAJ |
| description | The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activity of sirtuins and their role in the aging process. The effects of compounds that modulate the activity of sirtuins were discussed, and in numerous studies, their effectiveness was demonstrated. Attention was paid to the role of a caloric restriction and the risks associated with the influence of careless sirtuin modulation on the organism. It has been shown that low modulators’ bioavailability/retention time is a crucial problem for optimal regulation of the studied pathways. Therefore, a detailed understanding of the modulator structure and potential reactivity with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest achievements in nanobiotechnology make it possible to create promising molecules, but many of them remain in the sphere of plans and concepts. It seems that solving the mystery of longevity will have to wait for new scientific discoveries. |
| first_indexed | 2024-03-11T09:58:28Z |
| format | Article |
| id | doaj.art-feaed89669214089b10b7f49f51ff10f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:28Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-feaed89669214089b10b7f49f51ff10f2023-11-16T15:37:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124172810.3390/ijms24010728Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and FuturePatrycja Ziętara0Marta Dziewięcka1Maria Augustyniak2Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, ul. Bankowa 9, 40-007 Katowice, PolandFaculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, ul. Bankowa 9, 40-007 Katowice, PolandFaculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, ul. Bankowa 9, 40-007 Katowice, PolandThe sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activity of sirtuins and their role in the aging process. The effects of compounds that modulate the activity of sirtuins were discussed, and in numerous studies, their effectiveness was demonstrated. Attention was paid to the role of a caloric restriction and the risks associated with the influence of careless sirtuin modulation on the organism. It has been shown that low modulators’ bioavailability/retention time is a crucial problem for optimal regulation of the studied pathways. Therefore, a detailed understanding of the modulator structure and potential reactivity with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest achievements in nanobiotechnology make it possible to create promising molecules, but many of them remain in the sphere of plans and concepts. It seems that solving the mystery of longevity will have to wait for new scientific discoveries.https://www.mdpi.com/1422-0067/24/1/728sirtuinslongevitymodulators |
| spellingShingle | Patrycja Ziętara Marta Dziewięcka Maria Augustyniak Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future International Journal of Molecular Sciences sirtuins longevity modulators |
| title | Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future |
| title_full | Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future |
| title_fullStr | Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future |
| title_full_unstemmed | Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future |
| title_short | Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future |
| title_sort | why is longevity still a scientific mystery sirtuins past present and future |
| topic | sirtuins longevity modulators |
| url | https://www.mdpi.com/1422-0067/24/1/728 |
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