Ten Years Milestones in Xanthine Oxidase Inhibitors Discovery: Febuxostat-Based Inhibitors Trends, Bifunctional Derivatives, and Automatized Screening Assays

Ten Years Milestones in Xanthine Oxidase Inhibitors Discovery: Febuxostat-Based Inhibitors Trends, Bifunctional Derivatives, and Automatized Screening Assays

Xanthine oxidase (XO) is an enzyme involved in the oxidative process of hypoxanthine and xanthine to uric acid (UA). This process also produces reactive oxygen species (ROS) as byproducts. Both UA and ROS are dangerous for human health, and some health conditions trigger upregulation of XO activity,...

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Bibliographic Details
Main Authors: Miguel F. S. de Abreu, Camila A. Wegermann, Millena S. Ceroullo, Isabella G. M. Sant’Anna, Renato C. S. Lessa
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Organics
Subjects:
enzyme inhibition
drug development
drugs screening
allopurinol
febuxostat
Y-700
Online Access:https://www.mdpi.com/2673-401X/3/4/26

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