Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response
Psoriasis: Regulatory protein linked to chronic inflammation An immune-regulating protein that mediates chronic inflammation in the skin offers a new therapeutic target for the autoimmune disorder psoriasis. A research team from South Korea led by Chang-Woo Lee from Sungkyunkwan University School of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-09-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-00489-4 |
| _version_ | 1818408823525736448 |
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| author | Suhyeon Kim Si-Yeon Lee Seoyoon Bae Jin-Kwan Lee Kyungrim Hwang Heounjeong Go Chang-Woo Lee |
| author_facet | Suhyeon Kim Si-Yeon Lee Seoyoon Bae Jin-Kwan Lee Kyungrim Hwang Heounjeong Go Chang-Woo Lee |
| author_sort | Suhyeon Kim |
| collection | DOAJ |
| description | Psoriasis: Regulatory protein linked to chronic inflammation An immune-regulating protein that mediates chronic inflammation in the skin offers a new therapeutic target for the autoimmune disorder psoriasis. A research team from South Korea led by Chang-Woo Lee from Sungkyunkwan University School of Medicine in Suwon and Heounjeong Go from the University of Ulsan College of Medicine in Seoul have discovered that Pellino1, a protein known to modulate immune responses to pathogens, is also found in abundance in the skin lesions of people with psoriasis. Using mouse models, the researchers showed how Pellino1 induces the proliferation of certain skin cells and triggers an inflammatory state through the activation of small proteins and immune cells normally involved in defense against infection. Targeting strategy that inactivate Pellino1 could help blunt the inflammatory signaling in the skin that drives the development of psoriatic lesions. |
| first_indexed | 2024-12-14T09:49:51Z |
| format | Article |
| id | doaj.art-feb20285e80b4136a9b151670780e7d3 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-14T09:49:51Z |
| publishDate | 2020-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-feb20285e80b4136a9b151670780e7d32022-12-21T23:07:33ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-09-015291537154910.1038/s12276-020-00489-4Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 responseSuhyeon Kim0Si-Yeon Lee1Seoyoon Bae2Jin-Kwan Lee3Kyungrim Hwang4Heounjeong Go5Chang-Woo Lee6Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan UniversityDepartment of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical CenterDepartment of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of MedicinePsoriasis: Regulatory protein linked to chronic inflammation An immune-regulating protein that mediates chronic inflammation in the skin offers a new therapeutic target for the autoimmune disorder psoriasis. A research team from South Korea led by Chang-Woo Lee from Sungkyunkwan University School of Medicine in Suwon and Heounjeong Go from the University of Ulsan College of Medicine in Seoul have discovered that Pellino1, a protein known to modulate immune responses to pathogens, is also found in abundance in the skin lesions of people with psoriasis. Using mouse models, the researchers showed how Pellino1 induces the proliferation of certain skin cells and triggers an inflammatory state through the activation of small proteins and immune cells normally involved in defense against infection. Targeting strategy that inactivate Pellino1 could help blunt the inflammatory signaling in the skin that drives the development of psoriatic lesions.https://doi.org/10.1038/s12276-020-00489-4 |
| spellingShingle | Suhyeon Kim Si-Yeon Lee Seoyoon Bae Jin-Kwan Lee Kyungrim Hwang Heounjeong Go Chang-Woo Lee Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response Experimental and Molecular Medicine |
| title | Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response |
| title_full | Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response |
| title_fullStr | Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response |
| title_full_unstemmed | Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response |
| title_short | Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response |
| title_sort | pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the t helper 17 response |
| url | https://doi.org/10.1038/s12276-020-00489-4 |
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