pH-Sensitive Biomaterials for Drug Delivery
The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenviron...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/23/5649 |
| _version_ | 1797546205596614656 |
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| author | Shijie Zhuo Feng Zhang Junyu Yu Xican Zhang Guangbao Yang Xiaowen Liu |
| author_facet | Shijie Zhuo Feng Zhang Junyu Yu Xican Zhang Guangbao Yang Xiaowen Liu |
| author_sort | Shijie Zhuo |
| collection | DOAJ |
| description | The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials. |
| first_indexed | 2024-03-10T14:26:47Z |
| format | Article |
| id | doaj.art-feb30711d148467894533f583e6d64e4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:26:47Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-feb30711d148467894533f583e6d64e42023-11-20T23:00:17ZengMDPI AGMolecules1420-30492020-11-012523564910.3390/molecules25235649pH-Sensitive Biomaterials for Drug DeliveryShijie Zhuo0Feng Zhang1Junyu Yu2Xican Zhang3Guangbao Yang4Xiaowen Liu5Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, ChinaClinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, ChinaClinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, ChinaClinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, ChinaCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, ChinaClinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, ChinaThe development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads to the pathological tissues, producing enhanced therapeutic outcome and reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise for the purpose, which could protect the therapeutic payloads from metabolism and degradation during in vivo circulation and exhibit responsive release of the therapeutics triggered by the acidic pathological tissues, especially for cancer treatment. In the past decades, many methodologies, such as acidic cleavage linkage, have been applied for fabrication of pH-responsive materials for both in vitro and in vivo applications. In this review, we will summarize some pH-sensitive drug delivery system for medical application, mainly focusing on the pH-sensitive linkage bonds and pH-sensitive biomaterials.https://www.mdpi.com/1420-3049/25/23/5649pH sensitive biomaterialspH sensitive linkage bondsdrug delivery system |
| spellingShingle | Shijie Zhuo Feng Zhang Junyu Yu Xican Zhang Guangbao Yang Xiaowen Liu pH-Sensitive Biomaterials for Drug Delivery Molecules pH sensitive biomaterials pH sensitive linkage bonds drug delivery system |
| title | pH-Sensitive Biomaterials for Drug Delivery |
| title_full | pH-Sensitive Biomaterials for Drug Delivery |
| title_fullStr | pH-Sensitive Biomaterials for Drug Delivery |
| title_full_unstemmed | pH-Sensitive Biomaterials for Drug Delivery |
| title_short | pH-Sensitive Biomaterials for Drug Delivery |
| title_sort | ph sensitive biomaterials for drug delivery |
| topic | pH sensitive biomaterials pH sensitive linkage bonds drug delivery system |
| url | https://www.mdpi.com/1420-3049/25/23/5649 |
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