Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years
BackgroundAlthough epidemiological trends of childhood food sensitization (FS) in IgE-mediated food allergy were reported in China, few studies have examined at changes in its risk factors.ObjectiveTo investigate the change in early-life risk factors associated with childhood food sensitization duri...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153607/full |
| _version_ | 1797855236905238528 |
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| author | Zhuoying Ma Zhuoying Ma Lin Chen Lin Chen Ruoling Xian Ruoling Xian Heping Fang Heping Fang Jing Chen Jing Chen Haiqi Li Haiqi Li Juan Wang Juan Wang Yan Hu Yan Hu |
| author_facet | Zhuoying Ma Zhuoying Ma Lin Chen Lin Chen Ruoling Xian Ruoling Xian Heping Fang Heping Fang Jing Chen Jing Chen Haiqi Li Haiqi Li Juan Wang Juan Wang Yan Hu Yan Hu |
| author_sort | Zhuoying Ma |
| collection | DOAJ |
| description | BackgroundAlthough epidemiological trends of childhood food sensitization (FS) in IgE-mediated food allergy were reported in China, few studies have examined at changes in its risk factors.ObjectiveTo investigate the change in early-life risk factors associated with childhood food sensitization during 2009–2019 in China.MethodsData from two cross-sectional surveys conducted in 2009 and 2019 (401 and 513 children, respectively) were analyzed. The results of skin prick tests and information on food sensitization-related risk factors in children were summarized, including family history of atopic disease (FHA), demographic characteristics, method of delivery, feeding patterns, sibship size, pet ownership, and vitamin D supplementation. Binary logistic regression was used to calculate the odds ratio and the regression coefficient β-value of risk factors in the 2009 and 2019 surveys separately. Then, coefficient β-value differences between the two surveys were analyzed by the bdiff command in STATA to describe the change in risk factors over 10 years.ResultsThe 2009 survey revealed that FHA, age, only child, and feeding patterns were associated with food sensitization. The 2019 survey showed that food sensitization was affected by age, sex, and feeding patterns. However, from 2009 to 2019, the probability of food sensitization in the only-child group significantly increased by 226.0% (β-value difference = 0.81, P = 0.024) and decreased by 65.0% in female children (β-value difference = −1.06, P = 0.008). The effect of age on food sensitization decreased by 50.0% (β-value difference = −0.69, P < 0.001) over 10 years.ConclusionThe effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009−2019. However, the influence of demographic characteristics on food sensitization has changed since 2009; that is, older age, male gender, and only child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier ChiCTR1900024338. |
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| id | doaj.art-feb370e5a9194b52ae27a9a6ff3be708 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T20:20:26Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-feb370e5a9194b52ae27a9a6ff3be7082023-03-31T06:39:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11536071153607Changes in risk factors for food sensitization in early life: Analysis over a period of 10 yearsZhuoying Ma0Zhuoying Ma1Lin Chen2Lin Chen3Ruoling Xian4Ruoling Xian5Heping Fang6Heping Fang7Jing Chen8Jing Chen9Haiqi Li10Haiqi Li11Juan Wang12Juan Wang13Yan Hu14Yan Hu15Department of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaBackgroundAlthough epidemiological trends of childhood food sensitization (FS) in IgE-mediated food allergy were reported in China, few studies have examined at changes in its risk factors.ObjectiveTo investigate the change in early-life risk factors associated with childhood food sensitization during 2009–2019 in China.MethodsData from two cross-sectional surveys conducted in 2009 and 2019 (401 and 513 children, respectively) were analyzed. The results of skin prick tests and information on food sensitization-related risk factors in children were summarized, including family history of atopic disease (FHA), demographic characteristics, method of delivery, feeding patterns, sibship size, pet ownership, and vitamin D supplementation. Binary logistic regression was used to calculate the odds ratio and the regression coefficient β-value of risk factors in the 2009 and 2019 surveys separately. Then, coefficient β-value differences between the two surveys were analyzed by the bdiff command in STATA to describe the change in risk factors over 10 years.ResultsThe 2009 survey revealed that FHA, age, only child, and feeding patterns were associated with food sensitization. The 2019 survey showed that food sensitization was affected by age, sex, and feeding patterns. However, from 2009 to 2019, the probability of food sensitization in the only-child group significantly increased by 226.0% (β-value difference = 0.81, P = 0.024) and decreased by 65.0% in female children (β-value difference = −1.06, P = 0.008). The effect of age on food sensitization decreased by 50.0% (β-value difference = −0.69, P < 0.001) over 10 years.ConclusionThe effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009−2019. However, the influence of demographic characteristics on food sensitization has changed since 2009; that is, older age, male gender, and only child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier ChiCTR1900024338.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153607/fullchildrenfood sensitizationrisk factorchangeearly life |
| spellingShingle | Zhuoying Ma Zhuoying Ma Lin Chen Lin Chen Ruoling Xian Ruoling Xian Heping Fang Heping Fang Jing Chen Jing Chen Haiqi Li Haiqi Li Juan Wang Juan Wang Yan Hu Yan Hu Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years Frontiers in Immunology children food sensitization risk factor change early life |
| title | Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years |
| title_full | Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years |
| title_fullStr | Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years |
| title_full_unstemmed | Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years |
| title_short | Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years |
| title_sort | changes in risk factors for food sensitization in early life analysis over a period of 10 years |
| topic | children food sensitization risk factor change early life |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153607/full |
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