Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer’s Disease

Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer’s Disease

Five novel tacrine-ferulic acid hybrid compounds (8a–e) were synthesized and their structures were identified on the basis of a detailed spectroscopic analysis. The activities of inhibiting acetyl cholinesterase (AChE) and butyryl cholinesterase (BuChE), reducing self-induced β-amyloid (Aβ) aggregat...

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Bibliographic Details
Main Authors:	Yingbo Fu, Yu Mu, Hui Lei, Pu Wang, Xin Li, Qiao Leng, Li Han, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Format:	Article
Language:	English
Published:	MDPI AG 2016-10-01
Series:	Molecules
Subjects:	β-amyloid aggregation cholinesterase ferulic acid metal chelator tacrine neuroprotection
Online Access:	http://www.mdpi.com/1420-3049/21/10/1338

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