The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases
Dry eye disease (DED) is a multifactorial disease of the ocular surface system whose chore mechanisms are tear film instability, inflammation, tear hyperosmolarity and epithelial damage. In recent years, novel therapies specifically targeting inflammation and oxidative stress are being investigated...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/4/952 |
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| author | Marco Pellegrini Carlotta Senni Federico Bernabei Arrigo F. G. Cicero Aldo Vagge Antonio Maestri Vincenzo Scorcia Giuseppe Giannaccare |
| author_facet | Marco Pellegrini Carlotta Senni Federico Bernabei Arrigo F. G. Cicero Aldo Vagge Antonio Maestri Vincenzo Scorcia Giuseppe Giannaccare |
| author_sort | Marco Pellegrini |
| collection | DOAJ |
| description | Dry eye disease (DED) is a multifactorial disease of the ocular surface system whose chore mechanisms are tear film instability, inflammation, tear hyperosmolarity and epithelial damage. In recent years, novel therapies specifically targeting inflammation and oxidative stress are being investigated and used in this field. Therefore, an increasing body of evidence supporting the possible role of different micronutrients and nutraceutical products for the treatment of ocular surface diseases is now available. In the present review, we analyzed in detail the effects on ocular surface of omega-3 fatty acids, vitamins A, B12, C, D, selenium, curcumin and flavonoids. Among these, the efficacy of omega-3 fatty acid supplementation in ameliorating DED signs and symptoms is supported by robust scientific evidence. Further long-term clinical trials are warranted to confirm the safety and efficacy of the supplementation of the other micronutrients and nutraceuticals. |
| first_indexed | 2024-03-10T20:48:25Z |
| format | Article |
| id | doaj.art-feb4d4a22b5a4a629d9233b8d0db3f62 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:48:25Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-feb4d4a22b5a4a629d9233b8d0db3f622023-11-19T20:08:54ZengMDPI AGNutrients2072-66432020-03-0112495210.3390/nu12040952The Role of Nutrition and Nutritional Supplements in Ocular Surface DiseasesMarco Pellegrini0Carlotta Senni1Federico Bernabei2Arrigo F. G. Cicero3Aldo Vagge4Antonio Maestri5Vincenzo Scorcia6Giuseppe Giannaccare7Ophthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, ItalyOphthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, ItalyOphthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, ItalyMedical and Surgical Sciences Department, University of Bologna, 40138 Bologna, ItalyEye Clinic of Genoa, Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, 16132 Genoa, ItalyMedical Oncology Department, Santa Maria della Scaletta Hospital, 40026 Imola, ItalyDepartment of Ophthalmology, University Magna Græcia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Ophthalmology, University Magna Græcia of Catanzaro, 88100 Catanzaro, ItalyDry eye disease (DED) is a multifactorial disease of the ocular surface system whose chore mechanisms are tear film instability, inflammation, tear hyperosmolarity and epithelial damage. In recent years, novel therapies specifically targeting inflammation and oxidative stress are being investigated and used in this field. Therefore, an increasing body of evidence supporting the possible role of different micronutrients and nutraceutical products for the treatment of ocular surface diseases is now available. In the present review, we analyzed in detail the effects on ocular surface of omega-3 fatty acids, vitamins A, B12, C, D, selenium, curcumin and flavonoids. Among these, the efficacy of omega-3 fatty acid supplementation in ameliorating DED signs and symptoms is supported by robust scientific evidence. Further long-term clinical trials are warranted to confirm the safety and efficacy of the supplementation of the other micronutrients and nutraceuticals.https://www.mdpi.com/2072-6643/12/4/952ocular surfacedry eye diseasenutritional supplementsnutraceuticals |
| spellingShingle | Marco Pellegrini Carlotta Senni Federico Bernabei Arrigo F. G. Cicero Aldo Vagge Antonio Maestri Vincenzo Scorcia Giuseppe Giannaccare The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases Nutrients ocular surface dry eye disease nutritional supplements nutraceuticals |
| title | The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases |
| title_full | The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases |
| title_fullStr | The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases |
| title_full_unstemmed | The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases |
| title_short | The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases |
| title_sort | role of nutrition and nutritional supplements in ocular surface diseases |
| topic | ocular surface dry eye disease nutritional supplements nutraceuticals |
| url | https://www.mdpi.com/2072-6643/12/4/952 |
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