Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
Abstract The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-08-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01043-8 |
| _version_ | 1797699554581151744 |
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| author | Jinsook Son Domenico Accili |
| author_facet | Jinsook Son Domenico Accili |
| author_sort | Jinsook Son |
| collection | DOAJ |
| description | Abstract The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment. |
| first_indexed | 2024-03-12T04:10:29Z |
| format | Article |
| id | doaj.art-feb7725dc76e40a8bed0d2445f452ce4 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-12T04:10:29Z |
| publishDate | 2023-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-feb7725dc76e40a8bed0d2445f452ce42023-09-03T11:07:14ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-08-015581652165810.1038/s12276-023-01043-8Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetesJinsook Son0Domenico Accili1Department of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, Columbia UniversityDepartment of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, Columbia UniversityAbstract The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment.https://doi.org/10.1038/s12276-023-01043-8 |
| spellingShingle | Jinsook Son Domenico Accili Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes Experimental and Molecular Medicine |
| title | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
| title_full | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
| title_fullStr | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
| title_full_unstemmed | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
| title_short | Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes |
| title_sort | reversing pancreatic β cell dedifferentiation in the treatment of type 2 diabetes |
| url | https://doi.org/10.1038/s12276-023-01043-8 |
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