Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

The translocator protein (TSPO) is an interesting biological target for molecular imaging and therapy because the overexpression of TSPO is associated with microglial activation caused by neuronal damage or neuroinflammation, and these activated microglia are involved in various central nervous syst...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam, Sang-Yoon Lee
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	MDPI AG 2023-04-01
Cyfres:	Pharmaceuticals
Pynciau:	translocator protein (TSPO) microglia neuroinflammation neurodegenerative disease central nervous system (CNS) pyrazolopyrimidine
Mynediad Ar-lein:	https://www.mdpi.com/1424-8247/16/4/576

Eitemau Tebyg

Translocator protein (TSPO) is a biomarker of Zika virus (ZIKV) infection-associated neuroinflammation
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Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells
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Clinical Applications of TSPO PET for Glioma Imaging: Current Evidence and Future Perspective—A Systematic Review
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Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-<i>N</i>-(Pyridin-2-ylmethyl)Pyrazolo[1,5-<i>a</i>]Pyrimidin-7-Amines
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Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat model of Parkinson’s disease
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TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells
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The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects
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The <it>Arabidopsis </it>translocator protein (<it>At</it>TSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism
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The Interplay of Cholesterol and Ligand Binding in <i>h</i>TSPO from Classical Molecular Dynamics Simulations
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Characteristics of TSPO expression in marmoset EAE
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Comparative Assessment of TSPO Modulators on Electroencephalogram Activity and Exploratory Behavior
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