Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

The translocator protein (TSPO) is an interesting biological target for molecular imaging and therapy because the overexpression of TSPO is associated with microglial activation caused by neuronal damage or neuroinflammation, and these activated microglia are involved in various central nervous syst...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam, Sang-Yoon Lee
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2023-04-01
Schriftenreihe:Pharmaceuticals
Schlagworte:
translocator protein (TSPO)
microglia
neuroinflammation
neurodegenerative disease
central nervous system (CNS)
pyrazolopyrimidine
Online Zugang:https://www.mdpi.com/1424-8247/16/4/576

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