Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

The translocator protein (TSPO) is an interesting biological target for molecular imaging and therapy because the overexpression of TSPO is associated with microglial activation caused by neuronal damage or neuroinflammation, and these activated microglia are involved in various central nervous syst...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam, Sang-Yoon Lee
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: MDPI AG 2023-04-01
Sarja:Pharmaceuticals
Aiheet:
translocator protein (TSPO)
microglia
neuroinflammation
neurodegenerative disease
central nervous system (CNS)
pyrazolopyrimidine
Linkit:https://www.mdpi.com/1424-8247/16/4/576

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