Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

Synthesis, In Silico and In Vitro Characterization of Novel <i>N</i>,<i>N</i>-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO)

The translocator protein (TSPO) is an interesting biological target for molecular imaging and therapy because the overexpression of TSPO is associated with microglial activation caused by neuronal damage or neuroinflammation, and these activated microglia are involved in various central nervous syst...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam, Sang-Yoon Lee
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	MDPI AG 2023-04-01
Sraith:	Pharmaceuticals
Ábhair:	translocator protein (TSPO) microglia neuroinflammation neurodegenerative disease central nervous system (CNS) pyrazolopyrimidine
Rochtain ar líne:	https://www.mdpi.com/1424-8247/16/4/576

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