Absence of Mal/TIRAP Results in Abrogated Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed IFNβ and IFN-I Activated Gene Production

Absence of Mal/TIRAP Results in Abrogated Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed IFNβ and IFN-I Activated Gene Production

Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation of transcription factors, such as AP-1, NF-κB, and interferon regulatory factors (IRFs) and afterward to the induction of cytokines and anti-viral Type I IFNs. In genera...

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Bibliographic Details
Main Authors: Ewa Leszczyńska, Edyta Makuch, Małgorzata Mitkiewicz, Izabella Jasyk, Miwako Narita, Sabina Górska, Tomasz Lipiński, Jakub Siednienko
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
R848
R837
Toll-like receptor-7
Mal
IRF7
Interferon-beta
Online Access:https://www.mdpi.com/1422-0067/21/23/8925

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