A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature
In our case report, we discuss a 1-day-old boy presenting with blueberry muffin syndrome diagnosed with Langerhans cell histiocytosis. The diagnosis complicated by an initial difficult-to-interpret biopsy showing only a hint of perifollicular CD1a-positive cells; however, given our team’s strong cli...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-05-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X20919616 |
| _version_ | 1819055430056280064 |
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| author | Janelle Cyr Annie Langley Dina El Demellawy Michele Ramien |
| author_facet | Janelle Cyr Annie Langley Dina El Demellawy Michele Ramien |
| author_sort | Janelle Cyr |
| collection | DOAJ |
| description | In our case report, we discuss a 1-day-old boy presenting with blueberry muffin syndrome diagnosed with Langerhans cell histiocytosis. The diagnosis complicated by an initial difficult-to-interpret biopsy showing only a hint of perifollicular CD1a-positive cells; however, given our team’s strong clinical suspicion of Langerhans cell histiocytosis, a second biopsy of a more mature lesion was done and showed typical histopathology. This case introduces the possibility of perifollicular Langerhans cells early in this condition, demonstrates the importance of appropriate biopsy site selection, and highlights the importance of maintaining a high degree of suspicion when there is poor clinicopathologic correlation. Our case report contains a comprehensive table which reviews the systemic and cutaneous clinical features, as well as the laboratory, pathology, and imaging findings for the differential diagnoses of blueberry muffin baby. |
| first_indexed | 2024-12-21T13:07:23Z |
| format | Article |
| id | doaj.art-febb5b39fc994fd59e60bfddda1320af |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-21T13:07:23Z |
| publishDate | 2020-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-febb5b39fc994fd59e60bfddda1320af2022-12-21T19:02:58ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2020-05-01810.1177/2050313X20919616A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literatureJanelle Cyr0Annie Langley1Dina El Demellawy2Michele Ramien3Division of Dermatology, University of Toronto, Ottawa, ON, CanadaDivision of Dermatology, The Ottawa Hospital, Ottawa, ON, CanadaDivision of Pathology, Children’s Hospital of Eastern Ontario, Ottawa, ON, CanadaDivision of Rheumatology and Dermatology, Children’s Hospital of Eastern Ontario, Ottawa, ON, CanadaIn our case report, we discuss a 1-day-old boy presenting with blueberry muffin syndrome diagnosed with Langerhans cell histiocytosis. The diagnosis complicated by an initial difficult-to-interpret biopsy showing only a hint of perifollicular CD1a-positive cells; however, given our team’s strong clinical suspicion of Langerhans cell histiocytosis, a second biopsy of a more mature lesion was done and showed typical histopathology. This case introduces the possibility of perifollicular Langerhans cells early in this condition, demonstrates the importance of appropriate biopsy site selection, and highlights the importance of maintaining a high degree of suspicion when there is poor clinicopathologic correlation. Our case report contains a comprehensive table which reviews the systemic and cutaneous clinical features, as well as the laboratory, pathology, and imaging findings for the differential diagnoses of blueberry muffin baby.https://doi.org/10.1177/2050313X20919616 |
| spellingShingle | Janelle Cyr Annie Langley Dina El Demellawy Michele Ramien A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature SAGE Open Medical Case Reports |
| title | A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature |
| title_full | A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature |
| title_fullStr | A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature |
| title_full_unstemmed | A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature |
| title_short | A neonate with Langerhans cell histiocytosis presenting as blueberry muffin rash: Case report and review of the literature |
| title_sort | neonate with langerhans cell histiocytosis presenting as blueberry muffin rash case report and review of the literature |
| url | https://doi.org/10.1177/2050313X20919616 |
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