Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square
Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared s...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/23/6/1434 |
| _version_ | 1818603729949032448 |
|---|---|
| author | Mohammed S. M. Saleh Mohammad Jamshed Siddiqui Siti Zaiton Mat So’ad Fatimah Opeyemi Roheem Salima Saidi-Besbes Alfi Khatib |
| author_facet | Mohammed S. M. Saleh Mohammad Jamshed Siddiqui Siti Zaiton Mat So’ad Fatimah Opeyemi Roheem Salima Saidi-Besbes Alfi Khatib |
| author_sort | Mohammed S. M. Saleh |
| collection | DOAJ |
| description | Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity. |
| first_indexed | 2024-12-16T13:27:48Z |
| format | Article |
| id | doaj.art-fec07f69a3594ac298251658f6c0f430 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T13:27:48Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fec07f69a3594ac298251658f6c0f4302022-12-21T22:30:11ZengMDPI AGMolecules1420-30492018-06-01236143410.3390/molecules23061434molecules23061434Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least SquareMohammed S. M. Saleh0Mohammad Jamshed Siddiqui1Siti Zaiton Mat So’ad2Fatimah Opeyemi Roheem3Salima Saidi-Besbes4Alfi Khatib5Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Indera Mahkota, Kuantan 25200, Pahang, MalaysiaDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Indera Mahkota, Kuantan 25200, Pahang, MalaysiaDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Indera Mahkota, Kuantan 25200, Pahang, MalaysiaDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Indera Mahkota, Kuantan 25200, Pahang, MalaysiaLaboratoire de Synthèse Organique Appliquée, Faculté des Sciences Exactes et Appliquées, Département de Chimie, Université Oran1, BP 1524 El Mnaoueur, 31000 Oran, AlgérieDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Indera Mahkota, Kuantan 25200, Pahang, MalaysiaSalak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity.http://www.mdpi.com/1420-3049/23/6/1434α-glucosidase inhibitory activityfingerprintFourier transform infrared spectroscopysalak fruit |
| spellingShingle | Mohammed S. M. Saleh Mohammad Jamshed Siddiqui Siti Zaiton Mat So’ad Fatimah Opeyemi Roheem Salima Saidi-Besbes Alfi Khatib Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square Molecules α-glucosidase inhibitory activity fingerprint Fourier transform infrared spectroscopy salak fruit |
| title | Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square |
| title_full | Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square |
| title_fullStr | Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square |
| title_full_unstemmed | Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square |
| title_short | Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square |
| title_sort | correlation of ft ir fingerprint and α glucosidase inhibitory activity of salak salacca zalacca fruit extracts utilizing orthogonal partial least square |
| topic | α-glucosidase inhibitory activity fingerprint Fourier transform infrared spectroscopy salak fruit |
| url | http://www.mdpi.com/1420-3049/23/6/1434 |
| work_keys_str_mv | AT mohammedsmsaleh correlationofftirfingerprintandaglucosidaseinhibitoryactivityofsalaksalaccazalaccafruitextractsutilizingorthogonalpartialleastsquare AT mohammadjamshedsiddiqui correlationofftirfingerprintandaglucosidaseinhibitoryactivityofsalaksalaccazalaccafruitextractsutilizingorthogonalpartialleastsquare AT sitizaitonmatsoad correlationofftirfingerprintandaglucosidaseinhibitoryactivityofsalaksalaccazalaccafruitextractsutilizingorthogonalpartialleastsquare AT fatimahopeyemiroheem correlationofftirfingerprintandaglucosidaseinhibitoryactivityofsalaksalaccazalaccafruitextractsutilizingorthogonalpartialleastsquare AT salimasaidibesbes correlationofftirfingerprintandaglucosidaseinhibitoryactivityofsalaksalaccazalaccafruitextractsutilizingorthogonalpartialleastsquare AT alfikhatib correlationofftirfingerprintandaglucosidaseinhibitoryactivityofsalaksalaccazalaccafruitextractsutilizingorthogonalpartialleastsquare |