Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece
The aim of this study was to evaluate the effect of gestational weight gain (GWG) up to 23<sup>+6</sup> weeks of gestation on the incidence of Gestational Diabetes Mellitus (GDM). A pregnant cohort of 5948 women in Northern Greece was recruited. Anthropometric features before and during...
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/4/893 |
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| author | Antigoni Tranidou Emmanuela Magriplis Ioannis Tsakiridis Nikolaos Pazaras Aikaterini Apostolopoulou Michail Chourdakis Themistoklis Dagklis |
| author_facet | Antigoni Tranidou Emmanuela Magriplis Ioannis Tsakiridis Nikolaos Pazaras Aikaterini Apostolopoulou Michail Chourdakis Themistoklis Dagklis |
| author_sort | Antigoni Tranidou |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effect of gestational weight gain (GWG) up to 23<sup>+6</sup> weeks of gestation on the incidence of Gestational Diabetes Mellitus (GDM). A pregnant cohort of 5948 women in Northern Greece was recruited. Anthropometric features before and during pregnancy were recorded, the GWG by 23<sup>+6</sup> weeks was calculated and a Generalized Linear Regression Model (GLM) with subgroup analyses based on weight status were computed. GDM was diagnosed in 5.5% of women. GLM results showed that GDM likelihood increased with maternal age (MA) and pre-pregnancy BMI (aOR: 1.08, 95%CI: [1.06, 1.11] and aOR: 1.09, 95%CI: [1.09, 1.11], respectively). Ιn the normal pre-pregnancy weight group, when the extra weight gain was >8 kgs, the odds of GDM increased (OR: 2.13, 95%CI: [0.98, 4.21], <i>p</i> = 0.03). Women with pre-pregnancy level 2 clinical obesity (OB2 pre) (BMI > 35 and <40 kg/m<sup>2</sup>) that shifted to OB3 category (BMI ≥ 40 kg/m<sup>2</sup>) had an increased GDM likelihood (OR: 4.85, 95%CI: [1.50, 15.95]). Women of higher MA may require stricter monitoring for GDM from early pregnancy, while in obese women, recommended GWG may need to be re-evaluated, since refraining from any weight gain may have a preventive effect for GDM. |
| first_indexed | 2024-03-11T08:20:32Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T08:20:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-fec216b19be14730a32217ebdcac6b392023-11-16T22:30:25ZengMDPI AGNutrients2072-66432023-02-0115489310.3390/nu15040893Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern GreeceAntigoni Tranidou0Emmanuela Magriplis1Ioannis Tsakiridis2Nikolaos Pazaras3Aikaterini Apostolopoulou4Michail Chourdakis5Themistoklis Dagklis63rd Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 42 Thessaloniki, GreeceDepartment of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece3rd Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 42 Thessaloniki, GreeceLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece3rd Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 42 Thessaloniki, GreeceLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece3rd Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 546 42 Thessaloniki, GreeceThe aim of this study was to evaluate the effect of gestational weight gain (GWG) up to 23<sup>+6</sup> weeks of gestation on the incidence of Gestational Diabetes Mellitus (GDM). A pregnant cohort of 5948 women in Northern Greece was recruited. Anthropometric features before and during pregnancy were recorded, the GWG by 23<sup>+6</sup> weeks was calculated and a Generalized Linear Regression Model (GLM) with subgroup analyses based on weight status were computed. GDM was diagnosed in 5.5% of women. GLM results showed that GDM likelihood increased with maternal age (MA) and pre-pregnancy BMI (aOR: 1.08, 95%CI: [1.06, 1.11] and aOR: 1.09, 95%CI: [1.09, 1.11], respectively). Ιn the normal pre-pregnancy weight group, when the extra weight gain was >8 kgs, the odds of GDM increased (OR: 2.13, 95%CI: [0.98, 4.21], <i>p</i> = 0.03). Women with pre-pregnancy level 2 clinical obesity (OB2 pre) (BMI > 35 and <40 kg/m<sup>2</sup>) that shifted to OB3 category (BMI ≥ 40 kg/m<sup>2</sup>) had an increased GDM likelihood (OR: 4.85, 95%CI: [1.50, 15.95]). Women of higher MA may require stricter monitoring for GDM from early pregnancy, while in obese women, recommended GWG may need to be re-evaluated, since refraining from any weight gain may have a preventive effect for GDM.https://www.mdpi.com/2072-6643/15/4/893gestationaldiabetesGDMweightgaingeneralized linear model |
| spellingShingle | Antigoni Tranidou Emmanuela Magriplis Ioannis Tsakiridis Nikolaos Pazaras Aikaterini Apostolopoulou Michail Chourdakis Themistoklis Dagklis Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece Nutrients gestational diabetes GDM weight gain generalized linear model |
| title | Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece |
| title_full | Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece |
| title_fullStr | Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece |
| title_full_unstemmed | Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece |
| title_short | Effect of Gestational Weight Gain during the First Half of Pregnancy on the Incidence of GDM, Results from a Pregnant Cohort in Northern Greece |
| title_sort | effect of gestational weight gain during the first half of pregnancy on the incidence of gdm results from a pregnant cohort in northern greece |
| topic | gestational diabetes GDM weight gain generalized linear model |
| url | https://www.mdpi.com/2072-6643/15/4/893 |
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