Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model
The objective of this research is to propose a general model utilizing the solvatochromic polarity of electronic transition energy (ET) of the Reichardt indicator to predict paracetamol solubility in the solvent mixtures. In order to model validation, the available ET (30) values of nine aqueous mix...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | Liquids |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-8015/3/4/32 |
| _version_ | 1797380302635532288 |
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| author | Elaheh Rahimpour Abolghasem Jouyban |
| author_facet | Elaheh Rahimpour Abolghasem Jouyban |
| author_sort | Elaheh Rahimpour |
| collection | DOAJ |
| description | The objective of this research is to propose a general model utilizing the solvatochromic polarity of electronic transition energy (ET) of the Reichardt indicator to predict paracetamol solubility in the solvent mixtures. In order to model validation, the available ET (30) values of nine aqueous mixtures obtained from existing literature sources were utilized. The trained model yielded a relatively accurate estimation of paracetamol solubility in the investigated systems. |
| first_indexed | 2024-03-08T20:36:24Z |
| format | Article |
| id | doaj.art-fec49386bceb43e780c8428a5f73f13c |
| institution | Directory Open Access Journal |
| issn | 2673-8015 |
| language | English |
| last_indexed | 2024-03-08T20:36:24Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Liquids |
| spelling | doaj.art-fec49386bceb43e780c8428a5f73f13c2023-12-22T14:21:28ZengMDPI AGLiquids2673-80152023-12-013451252110.3390/liquids3040032Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined ModelElaheh Rahimpour0Abolghasem Jouyban1Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, IranPharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, IranThe objective of this research is to propose a general model utilizing the solvatochromic polarity of electronic transition energy (ET) of the Reichardt indicator to predict paracetamol solubility in the solvent mixtures. In order to model validation, the available ET (30) values of nine aqueous mixtures obtained from existing literature sources were utilized. The trained model yielded a relatively accurate estimation of paracetamol solubility in the investigated systems.https://www.mdpi.com/2673-8015/3/4/32paracetamolsolubility predictionReichardt indicatorbinary mixtures |
| spellingShingle | Elaheh Rahimpour Abolghasem Jouyban Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model Liquids paracetamol solubility prediction Reichardt indicator binary mixtures |
| title | Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model |
| title_full | Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model |
| title_fullStr | Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model |
| title_full_unstemmed | Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model |
| title_short | Prediction of Paracetamol Solubility in Binary Solvents Using Reichardt’s Polarity Parameter Combined Model |
| title_sort | prediction of paracetamol solubility in binary solvents using reichardt s polarity parameter combined model |
| topic | paracetamol solubility prediction Reichardt indicator binary mixtures |
| url | https://www.mdpi.com/2673-8015/3/4/32 |
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