The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer
Abstract This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC patients diagnosed by pathology who underwent surgery at Sun Yat-sen University Canc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-023-00527-0 |
| _version_ | 1797426965369585664 |
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| author | Danyang Zhou Mei Li Mohamed Hussein Yasin Qianyi Lu Jia Fu Kuikui Jiang Ruoxi Hong Shusen Wang Fei Xu |
| author_facet | Danyang Zhou Mei Li Mohamed Hussein Yasin Qianyi Lu Jia Fu Kuikui Jiang Ruoxi Hong Shusen Wang Fei Xu |
| author_sort | Danyang Zhou |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC patients diagnosed by pathology who underwent surgery at Sun Yat-sen University Cancer Center from 2016 to 2017 were included. AR+ and AR− breast IDC samples were matched 1:1 in age, T stage, and N stage for immune infiltration analysis. A total of 554 patients with HER2+ nonmetastatic breast cancer were included in this retrospective study, regardless of HR status. The cut-off value for AR was set at 10%. ER+ (p < 0.001) and PR+ (p < 0.001) were associated with positive AR expression. Kaplan–Meier survival curve analysis suggested that AR was closely correlated with overall survival (OS) (p = 0.001) but not disease-free survival (DFS) (p = 0.051). After eliminating the potential impact caused by HR, AR also predicted longer OS (p = 0.014) and was an independent predictive factor for OS of HER2+HR− nonmetastatic breast IDC patients, as revealed by multivariate analysis (p = 0.036). For AR+ and AR− matched HER2+HR− patients, TILs (p = 0.043) and PD-L1 (p = 0.027) levels were significantly lower in AR+ patients. The strongest negative correlation was observed between AR and PD-L1 (Pearson’s r = −0.299, p = 0.001). AR+ status was markedly related to better OS in HER2+HR− nonmetastatic breast cancer patients, while a negative correlation was observed between AR and PD-L1/TILs. We provide new insights into the prognostic value of AR and its association with the immune microenvironment to optimize treatment strategies in HER2+ nonmetastatic breast IDCs. |
| first_indexed | 2024-03-09T08:37:28Z |
| format | Article |
| id | doaj.art-fec4abbf38d44bed9aa5ae05b7cb8401 |
| institution | Directory Open Access Journal |
| issn | 2374-4677 |
| language | English |
| last_indexed | 2024-03-09T08:37:28Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj.art-fec4abbf38d44bed9aa5ae05b7cb84012023-12-02T17:52:45ZengNature Portfolionpj Breast Cancer2374-46772023-04-019111010.1038/s41523-023-00527-0The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancerDanyang Zhou0Mei Li1Mohamed Hussein Yasin2Qianyi Lu3Jia Fu4Kuikui Jiang5Ruoxi Hong6Shusen Wang7Fei Xu8Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineAbstract This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC patients diagnosed by pathology who underwent surgery at Sun Yat-sen University Cancer Center from 2016 to 2017 were included. AR+ and AR− breast IDC samples were matched 1:1 in age, T stage, and N stage for immune infiltration analysis. A total of 554 patients with HER2+ nonmetastatic breast cancer were included in this retrospective study, regardless of HR status. The cut-off value for AR was set at 10%. ER+ (p < 0.001) and PR+ (p < 0.001) were associated with positive AR expression. Kaplan–Meier survival curve analysis suggested that AR was closely correlated with overall survival (OS) (p = 0.001) but not disease-free survival (DFS) (p = 0.051). After eliminating the potential impact caused by HR, AR also predicted longer OS (p = 0.014) and was an independent predictive factor for OS of HER2+HR− nonmetastatic breast IDC patients, as revealed by multivariate analysis (p = 0.036). For AR+ and AR− matched HER2+HR− patients, TILs (p = 0.043) and PD-L1 (p = 0.027) levels were significantly lower in AR+ patients. The strongest negative correlation was observed between AR and PD-L1 (Pearson’s r = −0.299, p = 0.001). AR+ status was markedly related to better OS in HER2+HR− nonmetastatic breast cancer patients, while a negative correlation was observed between AR and PD-L1/TILs. We provide new insights into the prognostic value of AR and its association with the immune microenvironment to optimize treatment strategies in HER2+ nonmetastatic breast IDCs.https://doi.org/10.1038/s41523-023-00527-0 |
| spellingShingle | Danyang Zhou Mei Li Mohamed Hussein Yasin Qianyi Lu Jia Fu Kuikui Jiang Ruoxi Hong Shusen Wang Fei Xu The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer npj Breast Cancer |
| title | The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer |
| title_full | The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer |
| title_fullStr | The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer |
| title_full_unstemmed | The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer |
| title_short | The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer |
| title_sort | prognostic value and immune microenvironment association of ar in her2 nonmetastatic breast cancer |
| url | https://doi.org/10.1038/s41523-023-00527-0 |
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