The Insulin/IGF system in colorectal cancer development and resistance to therapy
The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the Insulin Receptor (IR), the IGF-1 Receptor (IG...
Main Authors: | Paolo Giovanni Vigneri, Elena eTirrò, Maria Stella ePennisi, Michele eMassimino, Stefania eStella, Chiara eRomano, Livia eManzella |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-10-01
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Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00230/full |
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