Hepatic tuberculosis in absence of disseminated abdominal tuberculosis
Liver involvement in tuberculosis in absence of miliary tuberculosis is rare. This study was performed to analyse the spectrum and response to treatment of hepatic tuberculosis in the absence of miliary abdominal tuberculosis. Retrospective analysis of seven cases of hepatic tuberculosis without mil...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-01-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119320381 |
| _version_ | 1818893149225877504 |
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| author | Chirag S. Desai Anand G. Joshi Philip Abraham Devendra C. Desai Ramesh B. Deshpande Anita Bhaduri Sudeep R. Shah |
| author_facet | Chirag S. Desai Anand G. Joshi Philip Abraham Devendra C. Desai Ramesh B. Deshpande Anita Bhaduri Sudeep R. Shah |
| author_sort | Chirag S. Desai |
| collection | DOAJ |
| description | Liver involvement in tuberculosis in absence of miliary tuberculosis is rare. This study was performed to analyse the spectrum and response to treatment of hepatic tuberculosis in the absence of miliary abdominal tuberculosis. Retrospective analysis of seven cases of hepatic tuberculosis without miliary abdominal tuberculosis who presented at the single tertiary referral center were analyzed. All patients presented with fever and hepatomegaly. Five of them had pain in upper abdomen and vomiting. HIV serology was positive in one patient. All patients had normocytic normochromic anaemia, raised erythrocyte sedimentation rate (Mean 65). Mild elevation of liver enzymes and low albumin (Mean 2.4 gm%) with reversal of albumin globulin ratio (Mean 0.6) were seen in all. Two had jaundice. Prothrombin time was normal in all and lactate dehydrogenase values were elevated in all (Mean 794 IU/L). On ultrasonography, 2 had multiple hypodense lesion, 1 had coarse echotexture of liver, 1had hyperechoic pattern and 3 had just hepatomegaly. Complete resolution of liver lesions on treatment with 4-drug anti-tuberculosis drug chemotherapy was seen. In conclusion, liver tuberculosis has protean manifestations with nonspecific alteration of liver function tests and is best diagnosed on liver biopsy. Overall response to therapy is satisfactory. |
| first_indexed | 2024-12-19T18:08:00Z |
| format | Article |
| id | doaj.art-fec924673474478581d77f7cdc91e02f |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-19T18:08:00Z |
| publishDate | 2006-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-fec924673474478581d77f7cdc91e02f2022-12-21T20:11:23ZengElsevierAnnals of Hepatology1665-26812006-01-01514143Hepatic tuberculosis in absence of disseminated abdominal tuberculosisChirag S. Desai0Anand G. Joshi1Philip Abraham2Devendra C. Desai3Ramesh B. Deshpande4Anita Bhaduri5Sudeep R. Shah6Divisions of GI Surgery, Gastroenterology.Divisions of GI Surgery, Gastroenterology.Divisions of GI Surgery, Gastroenterology.Divisions of GI Surgery, Gastroenterology.Surgical Pathology. P.D. Hinduja Hospital and Medical Research CenterSurgical Pathology. P.D. Hinduja Hospital and Medical Research CenterSurgical Pathology. P.D. Hinduja Hospital and Medical Research Center; Address for correspondence:Liver involvement in tuberculosis in absence of miliary tuberculosis is rare. This study was performed to analyse the spectrum and response to treatment of hepatic tuberculosis in the absence of miliary abdominal tuberculosis. Retrospective analysis of seven cases of hepatic tuberculosis without miliary abdominal tuberculosis who presented at the single tertiary referral center were analyzed. All patients presented with fever and hepatomegaly. Five of them had pain in upper abdomen and vomiting. HIV serology was positive in one patient. All patients had normocytic normochromic anaemia, raised erythrocyte sedimentation rate (Mean 65). Mild elevation of liver enzymes and low albumin (Mean 2.4 gm%) with reversal of albumin globulin ratio (Mean 0.6) were seen in all. Two had jaundice. Prothrombin time was normal in all and lactate dehydrogenase values were elevated in all (Mean 794 IU/L). On ultrasonography, 2 had multiple hypodense lesion, 1 had coarse echotexture of liver, 1had hyperechoic pattern and 3 had just hepatomegaly. Complete resolution of liver lesions on treatment with 4-drug anti-tuberculosis drug chemotherapy was seen. In conclusion, liver tuberculosis has protean manifestations with nonspecific alteration of liver function tests and is best diagnosed on liver biopsy. Overall response to therapy is satisfactory.http://www.sciencedirect.com/science/article/pii/S1665268119320381LivergranulomaM tuberculosis |
| spellingShingle | Chirag S. Desai Anand G. Joshi Philip Abraham Devendra C. Desai Ramesh B. Deshpande Anita Bhaduri Sudeep R. Shah Hepatic tuberculosis in absence of disseminated abdominal tuberculosis Annals of Hepatology Liver granuloma M tuberculosis |
| title | Hepatic tuberculosis in absence of disseminated abdominal tuberculosis |
| title_full | Hepatic tuberculosis in absence of disseminated abdominal tuberculosis |
| title_fullStr | Hepatic tuberculosis in absence of disseminated abdominal tuberculosis |
| title_full_unstemmed | Hepatic tuberculosis in absence of disseminated abdominal tuberculosis |
| title_short | Hepatic tuberculosis in absence of disseminated abdominal tuberculosis |
| title_sort | hepatic tuberculosis in absence of disseminated abdominal tuberculosis |
| topic | Liver granuloma M tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119320381 |
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