Prediction of Molecular Initiating Events for Adverse Outcome Pathways Using High-Throughput Identification of Chemical Targets

Prediction of Molecular Initiating Events for Adverse Outcome Pathways Using High-Throughput Identification of Chemical Targets

The impact of exposure to multiple chemicals raises concerns for human and environmental health. The adverse outcome pathway method offers a framework to support mechanism-based assessment in environmental health starting by describing which mechanisms are triggered upon interaction with different s...

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Bibliographic Details
Main Authors: Veronica Lizano-Fallas, Ana Carrasco del Amor, Susana Cristobal
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Toxics
Subjects:
molecular initiating event
adverse outcome pathway
chemical target
proteome integral solubility alteration assay
thermal proteome profiling
predictive toxicology
Online Access:https://www.mdpi.com/2305-6304/11/2/189

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