Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model
Local recurrence of colorectal cancer (CRC) can occur in patients after curative resection, and additional surgical resection may therefore be required; however, this is a significant burden for patients, because additional surgical resection may necessitate the resection of other organs such as the...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222010216 |
| _version_ | 1811273768502296576 |
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| author | Jun Arima Kohei Taniguchi Masashi Yamamoto Tsubasa Watanabe Yusuke Suzuki Hiroki Hamamoto Yosuke Inomata Hideki Kashiwagi Shinji Kawabata Keitaro Tanaka Kazuhisa Uchiyama Minoru Suzuki Sang-Woong Lee |
| author_facet | Jun Arima Kohei Taniguchi Masashi Yamamoto Tsubasa Watanabe Yusuke Suzuki Hiroki Hamamoto Yosuke Inomata Hideki Kashiwagi Shinji Kawabata Keitaro Tanaka Kazuhisa Uchiyama Minoru Suzuki Sang-Woong Lee |
| author_sort | Jun Arima |
| collection | DOAJ |
| description | Local recurrence of colorectal cancer (CRC) can occur in patients after curative resection, and additional surgical resection may therefore be required; however, this is a significant burden for patients, because additional surgical resection may necessitate the resection of other organs such as the bladder, prostate, uterus, or sacral bone. Therefore, there is a need for alternative therapeutic strategies. We focused on boron neutron capture therapy (BNCT) as a treatment modality that can selectively target tumor cells without excessive damage to normal tissues. The usefulness of BNCT to pelvic CRC remains unknown. This study investigated the anti-cancer effect of boronophenylalanine (BPA)-mediated BNCT in a previously established mouse model of pelvic recurrence of CRC. Uptake of BPA in CRC was observed both in vitro and in vivo, and the concentrations were sufficient for BNCT. Our results are the first to show that BPA-mediated BNCT prolonged the survival of experimental mice with pelvic tumors; moreover, it did not cause any obvious severe side effects in the treated animals. In conclusion, BPA-mediated BNCT could contribute to treating local recurrence of pelvic CRC. |
| first_indexed | 2024-04-12T23:05:19Z |
| format | Article |
| id | doaj.art-fecb0421e4274fea8e627e7461d750f7 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T23:05:19Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-fecb0421e4274fea8e627e7461d750f72022-12-22T03:12:56ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-10-01154113632Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse modelJun Arima0Kohei Taniguchi1Masashi Yamamoto2Tsubasa Watanabe3Yusuke Suzuki4Hiroki Hamamoto5Yosuke Inomata6Hideki Kashiwagi7Shinji Kawabata8Keitaro Tanaka9Kazuhisa Uchiyama10Minoru Suzuki11Sang-Woong Lee12Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanTranslational Research Program, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, Japan; Corresponding author.Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of Particle Radiation Oncology, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2 Asashiro- Nishi, Kumatori-cho, Sennan-gun, Osaka 590–0494, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of Neurosurgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of Neurosurgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanDepartment of Particle Radiation Oncology, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2 Asashiro- Nishi, Kumatori-cho, Sennan-gun, Osaka 590–0494, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2–7 Daigaku-machi, Takatsuki, Osaka 569–8686, JapanLocal recurrence of colorectal cancer (CRC) can occur in patients after curative resection, and additional surgical resection may therefore be required; however, this is a significant burden for patients, because additional surgical resection may necessitate the resection of other organs such as the bladder, prostate, uterus, or sacral bone. Therefore, there is a need for alternative therapeutic strategies. We focused on boron neutron capture therapy (BNCT) as a treatment modality that can selectively target tumor cells without excessive damage to normal tissues. The usefulness of BNCT to pelvic CRC remains unknown. This study investigated the anti-cancer effect of boronophenylalanine (BPA)-mediated BNCT in a previously established mouse model of pelvic recurrence of CRC. Uptake of BPA in CRC was observed both in vitro and in vivo, and the concentrations were sufficient for BNCT. Our results are the first to show that BPA-mediated BNCT prolonged the survival of experimental mice with pelvic tumors; moreover, it did not cause any obvious severe side effects in the treated animals. In conclusion, BPA-mediated BNCT could contribute to treating local recurrence of pelvic CRC.http://www.sciencedirect.com/science/article/pii/S0753332222010216Boron neutron capture therapyColorectal cancerPelvic recurrenceBoronophenylalanine |
| spellingShingle | Jun Arima Kohei Taniguchi Masashi Yamamoto Tsubasa Watanabe Yusuke Suzuki Hiroki Hamamoto Yosuke Inomata Hideki Kashiwagi Shinji Kawabata Keitaro Tanaka Kazuhisa Uchiyama Minoru Suzuki Sang-Woong Lee Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model Biomedicine & Pharmacotherapy Boron neutron capture therapy Colorectal cancer Pelvic recurrence Boronophenylalanine |
| title | Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model |
| title_full | Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model |
| title_fullStr | Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model |
| title_full_unstemmed | Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model |
| title_short | Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model |
| title_sort | anti tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model |
| topic | Boron neutron capture therapy Colorectal cancer Pelvic recurrence Boronophenylalanine |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222010216 |
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