Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10730 |
| _version_ | 1818957022735892480 |
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| author | Alexis Saintamand Christelle Vincent-Fabert Armand Garot Pauline Rouaud Zeliha Oruc Virginie Magnone Michel Cogné Yves Denizot |
| author_facet | Alexis Saintamand Christelle Vincent-Fabert Armand Garot Pauline Rouaud Zeliha Oruc Virginie Magnone Michel Cogné Yves Denizot |
| author_sort | Alexis Saintamand |
| collection | DOAJ |
| description | The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity. |
| first_indexed | 2024-12-20T11:03:15Z |
| format | Article |
| id | doaj.art-fecbd343ebf14565a1611923292c4611 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T11:03:15Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fecbd343ebf14565a1611923292c46112022-12-21T19:42:58ZengNature PortfolioNature Communications2041-17232016-02-017111310.1038/ncomms10730Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory regionAlexis Saintamand0Christelle Vincent-Fabert1Armand Garot2Pauline Rouaud3Zeliha Oruc4Virginie Magnone5Michel Cogné6Yves Denizot7Université de Limoges, CRIBL, UMR CNRS 7276Université de Limoges, CRIBL, UMR CNRS 7276Université de Limoges, CRIBL, UMR CNRS 7276Université de Limoges, CRIBL, UMR CNRS 7276Université de Limoges, CRIBL, UMR CNRS 7276CNRS et Université de Nice Sophia Antipolis, Institut de Pharmacologie Moléculaire et CellulaireUniversité de Limoges, CRIBL, UMR CNRS 7276Université de Limoges, CRIBL, UMR CNRS 7276The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity.https://doi.org/10.1038/ncomms10730 |
| spellingShingle | Alexis Saintamand Christelle Vincent-Fabert Armand Garot Pauline Rouaud Zeliha Oruc Virginie Magnone Michel Cogné Yves Denizot Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region Nature Communications |
| title | Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region |
| title_full | Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region |
| title_fullStr | Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region |
| title_full_unstemmed | Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region |
| title_short | Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region |
| title_sort | deciphering the importance of the palindromic architecture of the immunoglobulin heavy chain 3 regulatory region |
| url | https://doi.org/10.1038/ncomms10730 |
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