Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C
Aim. To study characteristics of leukocytic infiltration of the liver in patients with chronic viral hepatitis B and C (CVHB and CVHC) with consideration of hepatitis activity and fibrosis severity. Material and methods. The examination of 37 patients with CVHB (n = 13) and CVHC (n = 24) included li...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2011-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30928 |
| _version_ | 1811213670765559808 |
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| author | Karina Turakbaevna Umbetova Anna Svyatoslavovna Lazareva Mikhail Valentinovich Kiselevskiy Yuriy Georgievich Parkhomenko Elena Vasil'evna Volchkova Sergey Grigor'evich Pak K T Umbetova A S Lazareva M V Kiselevsky Yu G Parkhomenko E V Volchkova S G Pak |
| author_facet | Karina Turakbaevna Umbetova Anna Svyatoslavovna Lazareva Mikhail Valentinovich Kiselevskiy Yuriy Georgievich Parkhomenko Elena Vasil'evna Volchkova Sergey Grigor'evich Pak K T Umbetova A S Lazareva M V Kiselevsky Yu G Parkhomenko E V Volchkova S G Pak |
| author_sort | Karina Turakbaevna Umbetova |
| collection | DOAJ |
| description | Aim. To study characteristics of leukocytic infiltration of the liver in patients with chronic viral hepatitis B and C (CVHB and CVHC) with consideration of hepatitis activity and fibrosis severity.
Material and methods. The examination of 37 patients with CVHB (n = 13) and CVHC (n = 24) included liver puncture biopsy by Mengini, subsequent histological and morphological investigation of liver biopsy with immunohisto- and immunocytochemistry.
Results. In CVHB and CVHC patients leukocytic infiltrates (LI) of the liver present primarily with T-lymphocytes (CD3+), NKT cells (CD3+CD16+CD56+), NK cells (CD16+CD56+), T-regulatory lymphocytes (CD4+CD25+), cytotoxic T-lymphocytes (CD8+). Cytotoxic lymphocytes (CD8+) and NK cells (CD16+CD56+) detected in hepatic LI of patients with chronic viral hepatitis are similar in composition with cells in hepatic tissue infiltrates in autoimmune hepatitis. We are the first to detect the complex of T-regulatory cells (CD4+CD25+)in hepatic parenchyma of these patients. This complex suppresses cellular immune response in virus elimination and damaged tissues and supports development of persistent viral infection with autoimmune component.
Conclusion. The complex of T-regulatory cells (CD4+CD25+) isolated in hepatic LI evidences for existence of a morphofunctional base for autoimmune manifestations in the presence of persistent viral infection. |
| first_indexed | 2024-04-12T05:50:12Z |
| format | Article |
| id | doaj.art-fecc23f2ed904c7baeca36efc7e707e3 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T05:50:12Z |
| publishDate | 2011-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-fecc23f2ed904c7baeca36efc7e707e32022-12-22T03:45:20Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-11-018311313327944Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and CKarina Turakbaevna UmbetovaAnna Svyatoslavovna LazarevaMikhail Valentinovich KiselevskiyYuriy Georgievich ParkhomenkoElena Vasil'evna VolchkovaSergey Grigor'evich PakK T Umbetova0A S Lazareva1M V Kiselevsky2Yu G Parkhomenko3E V Volchkova4S G Pak5I.M. Sechenov First Moscow State UniversityI.M. Sechenov First Moscow State UniversityN.N. Blokhin Cancer Research Center, MoscowInfection hospital N 2, MoscowI.M. Sechenov First Moscow State UniversityI.M. Sechenov First Moscow State UniversityAim. To study characteristics of leukocytic infiltration of the liver in patients with chronic viral hepatitis B and C (CVHB and CVHC) with consideration of hepatitis activity and fibrosis severity. Material and methods. The examination of 37 patients with CVHB (n = 13) and CVHC (n = 24) included liver puncture biopsy by Mengini, subsequent histological and morphological investigation of liver biopsy with immunohisto- and immunocytochemistry. Results. In CVHB and CVHC patients leukocytic infiltrates (LI) of the liver present primarily with T-lymphocytes (CD3+), NKT cells (CD3+CD16+CD56+), NK cells (CD16+CD56+), T-regulatory lymphocytes (CD4+CD25+), cytotoxic T-lymphocytes (CD8+). Cytotoxic lymphocytes (CD8+) and NK cells (CD16+CD56+) detected in hepatic LI of patients with chronic viral hepatitis are similar in composition with cells in hepatic tissue infiltrates in autoimmune hepatitis. We are the first to detect the complex of T-regulatory cells (CD4+CD25+)in hepatic parenchyma of these patients. This complex suppresses cellular immune response in virus elimination and damaged tissues and supports development of persistent viral infection with autoimmune component. Conclusion. The complex of T-regulatory cells (CD4+CD25+) isolated in hepatic LI evidences for existence of a morphofunctional base for autoimmune manifestations in the presence of persistent viral infection.https://ter-arkhiv.ru/0040-3660/article/view/30928chronic viral hepatitis b and chistological activity indexautoimmune manifestations |
| spellingShingle | Karina Turakbaevna Umbetova Anna Svyatoslavovna Lazareva Mikhail Valentinovich Kiselevskiy Yuriy Georgievich Parkhomenko Elena Vasil'evna Volchkova Sergey Grigor'evich Pak K T Umbetova A S Lazareva M V Kiselevsky Yu G Parkhomenko E V Volchkova S G Pak Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C Терапевтический архив chronic viral hepatitis b and c histological activity index autoimmune manifestations |
| title | Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C |
| title_full | Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C |
| title_fullStr | Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C |
| title_full_unstemmed | Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C |
| title_short | Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C |
| title_sort | specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis b and c |
| topic | chronic viral hepatitis b and c histological activity index autoimmune manifestations |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30928 |
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